126 citations
,
November 1987 in “The Journal of Pediatrics” This study reports that selenium deficiency in children on long-term total parenteral nutrition may lead to symptoms like erythrocyte macrocytosis and skin and hair depigmentation, which improved with selenium supplementation.
73 citations
,
May 1976 in “JAMA” This case report associates severe zinc deficiency with long-term total parenteral nutrition, suggesting the need for trace element supplementation in such nutritional management.
50 citations
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May 1985 in “The journal of pediatrics/The Journal of pediatrics” This study reported successful treatment of biotin deficiency in three patients receiving total parenteral nutrition, suggesting current biotin supplementation recommendations may be inadequate to maintain normal biotin status.
26 citations
,
February 1978 in “Journal of Pediatric Surgery” This study found that long-term total parenteral nutrition in pediatric patients led to severe zinc deficiency, which improved with intravenous zinc therapy, highlighting the need for adequate zinc inclusion in nutritional solutions.
22 citations
,
April 2015 in “Current problems in dermatology” Human hair follicles have a unique metabolism that changes between growth stages and may contribute to baldness.