This study identified the TALE homeodomain transcription factor Meis2 as a crucial regulator for the maturation and end-organ innervation of certain mechanoreceptors in mice, with its absence leading to altered sensory neuron structure and impaired touch sensitivity.
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June 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This symposium discussed recent advances in understanding skin as a sensory organ, emphasizing the interactions between itch, pain, and touch pathways and highlighting potential therapeutic targets.
This study found that the transcription factor Meis2 is crucial for the maturation and innervation of sensory neurons responsible for light touch in mice, with its absence leading to reduced touch sensitivity.
This study found that the transcription factor Meis2 regulates the maturation and innervation of sensory neurons in mice, affecting their response to light touch.
September 2024 in “Journal of the American Academy of Dermatology” This study reports that oxytocin receptor expression in keratinocytes shows a potential relationship with touch sensory neurons, suggesting a role in skin sensitivity and the broader function of sensory neurons.