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An Unusual Anatomical Colocalization of Alopecia Areata and Vitiligo in a Child, and Improvement During Treatment with Topical Prostaglandin E2

research An unusual anatomical colocalization of alopecia areata and vitiligo in a child, and improvement during treatment with topical prostaglandin E2

14 citations , November 2009 in “Clinical and experimental dermatology”

This article presents a case report of a child with coexisting alopecia areata and vitiligo showing improvement with topical prostaglandin E2 treatment, without reporting new clinical results.

research Evaluation of methotrexate-loaded surfactants, ceramides and cholesterol-based lamellar phases as a topical treatment for psoriasis

2 citations , February 2022 in “Journal of Pharmacy and Pharmacology”

In this study, two methotrexate-loaded liquid crystal formulations for topical application showed immunomodulatory effects and induced skin changes in mice with imiquimod-induced psoriasis.

research Minoxidil: mechanisms of action on hair growth

397 citations , February 2004 in “British Journal of Dermatology”

This article reviews the mechanisms by which minoxidil stimulates hair growth and reports no new clinical findings.

UV Light May Induce Hypertrichosis Through Production of Prostaglandin E2

research UV light may induce hypertrichosis through production of PGE2

7 citations , October 2006 in “Medical hypotheses”

UV light might cause excessive hair growth by increasing PGE2 in the skin.

Molecular Cloning and Expression Analysis of Prostaglandin E Receptor 2 Gene in Cashmere Goat (Capra hircus) Skin During Hair Follicle Development

research Molecular Cloning and Expression Analysis of Prostaglandin E Receptor 2 Gene in Cashmere Goat (Capra hircus) Skin during Hair Follicle Development

2 citations , February 2014 in “Animal Biotechnology”

This study reported that the PTGER2 gene is strongly expressed in cashmere goat skin and its expression tends to decrease from the anagen to telogen stages of the hair follicle cycle.

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Community Join

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community Painkillers May Block Minoxidil

12 upvotes 1 year ago

Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.

community What all oils could be useful to augment hair growth

4 upvotes 2 years ago

The user uses 1mg fin every other day, a topical solution of 5% min + 0.1% fin nightly, and seeks advice on oils for hair growth. Replies suggest oils are ineffective and recommend sticking with fin and min treatments.

community Doubts about castor oil

5 upvotes 7 years ago

Castor oil's effectiveness for hair growth is debated, with concerns about its impact on skin health and prostaglandin levels. Some users suggest combining it with coconut oil and using it alongside finasteride for better results, while others recommend sticking to proven synthetic treatments.

community Anyone using Peppermint oil/ similar oils and seeing growth?

5 upvotes 2 years ago

Peppermint oil may be beneficial for hair growth, potentially outperforming minoxidil. Users discuss its effectiveness compared to other treatments like finasteride and RU58841.

community PP405 Won’t Work: Follicle Is Miniaturized, Fibrosed, And Missing Key Support Cells

7 months ago

PP405 is ineffective for miniaturized, fibrosed hair follicles in androgenetic alopecia. AMP303 may activate hair follicle stem cells, but minoxidil and finasteride are still the main treatments.

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Learn

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learn Cetirizine

How does cetirizine reduce inflammation linked to hair loss? Cetirizine is proposed to lower prostaglandin D2 and raise prostaglandin E2 around hair follicles; three small trials of a compounded 1% topical report modest increases in hair density and shaft thickness, with minoxidil doing better head-to-head. Topical cetirizine is off-label and unapproved for hair loss, and the evidence is too thin to call it effective or safe.

learn Minoxidil

An essential vasodilator with some anti-androgenic effects

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