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    GlossaryTopical JAK Inhibitors

    medications applied to skin to block Janus kinase enzymes

    Topical JAK Inhibitors, also known as Topical Janus Kinase Inhibitors or Topical JAKis, are medications applied directly to the skin to block the activity of Janus kinase enzymes. These enzymes play a role in the immune response and inflammation. By inhibiting them, these treatments can help manage conditions like alopecia areata, an autoimmune disorder that causes hair loss, by reducing inflammation and potentially promoting hair regrowth.

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      learn Fluridil

      a topical anti-androgen with less systemic involvement

      learn Spironolactone

      powerful topical and oral anti-androgen used mostly by women

      learn Clascoterone

      a novel topical treatment that inhibits DHT on androgen receptors

      learn RU58841

      a potent but unapproved and potentially problematic topical anti-androgen

      learn Melatonin

      hormone commonly taken for sleep aid has some topical benefits for hair

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      community What else is good. Besides the big 3.

      in Chat  36 upvotes 1 month ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community 8 months apart on the mother of all stacks

      in Progress Pictures  151 upvotes 1 year ago
      User Tricky9555 tried various hair loss treatments for 8 months with no visible results. Others suggested considering a hair transplant, checking thyroid levels, and being patient for up to 24 months for potential results.

      community 4 months topical minoxidil + 2 months finasteride

      in Minoxidil  132 upvotes 1 week ago
      Topical minoxidil and oral finasteride are effectively promoting hair growth with minimal side effects, such as no impact on sex drive. Users report positive results and reduced hair shedding, with some using a combination of topical foam containing both minoxidil and finasteride.