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community Anyone on topical fin using glycerin instead of PG as humectant?

1 upvotes 7 months ago

Switching to a DIY topical finasteride solution using ethanol, glycerin, and distilled water instead of propylene glycol for a gentler application. Users report positive results with both DIY solutions and a low PG minoxidil and finasteride product from India.

community Creating Custom Topicals: A Guide (2025 Edition)

27 upvotes 10 months ago

Creating custom topical treatments for hair loss using minoxidil, finasteride, and RU58841. It includes recipes and instructions for home preparation, focusing on cost savings and customization.

community Does anyone know the chemical formula for pelage pp405?

15 upvotes 1 year ago

The conversation discusses the lack of public information on the chemical structure of PP405, a hair loss treatment, and the challenges of synthesizing it without a patent. It also explores a patent related to hydrogen-based topical formulations for reducing oxidative stress and inflammation.

community For pg free minoxidil, why not use propanediol instead of glycerin?

2 upvotes 4 months ago

The conversation discusses using propanediol as an alternative to glycerin in PG-free minoxidil for better absorption. The user also plans to try nanoxidil, which may absorb more easily due to its smaller molecule size.

community Grow Gorgeous Intense Hair Density Serum, 2.02 fl oz, 2-pack from Costco

1 year ago

The user is considering using "Grow Gorgeous Intense Hair Density Serum" alongside Minoxidil and is currently taking Finasteride. Some users doubt the serum's effectiveness, while others suggest it may help with hair strength and thickness, but opinions are mixed.

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Research

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Autosomal Recessive Congenital Ichthyosis Due to PNPLA1 Mutation in a Golden Retriever–Poodle Cross-Bred Dog and the Effect of Topical Therapy

research Autosomal recessive congenital ichthyosis due to PNPLA1 mutation in a golden retriever–poodle cross‐bred dog and the effect of topical therapy

9 citations , May 2016 in “Veterinary dermatology”

This case report describes how a long-term combination of oral fatty acids and topical therapy appeared beneficial for managing autosomal recessive congenital ichthyosis in a goldendoodle with a PNPLA1 mutation.

research Circle Hairs in a Patient with Multiple Myeloma

November 2021 in “Clinical, cosmetic and investigational dermatology”

This case report details an 80-year-old woman with circle hair potentially linked to acquired ichthyosis from multiple myeloma, where a prescribed topical treatment led to clinical improvement.

research Glycerol Regulates Stratum Corneum Hydration in Sebaceous Gland Deficient (Asebia) Mice

216 citations , May 2003 in “Journal of Investigative Dermatology”

This study found that sebaceous-gland-derived glycerol significantly contributes to stratum corneum hydration in mice with sebaceous gland deficiencies.

research Review on Herbal Hair Serum

October 2025 in “Research Journal of Topical and Cosmetic Sciences”

This study evaluated a herbal scalp serum containing Phyllanthus Emblica, hibiscus, Vitamin E, aloe Vera, and citrus oil, finding it stable and possessing good antibacterial activity.

A Multicenter Placebo-Controlled Clinical Trial on the Efficacy of Oral Ciclosporin A in the Treatment of Canine Idiopathic Sebaceous Adenitis Compared with Conventional Topical Treatment

research A multicentre placebo‐controlled clinical trial on the efficacy of oral ciclosporin A in the treatment of canine idiopathic sebaceous adenitis in comparison with conventional topical treatment

24 citations , May 2010 in “Veterinary dermatology”

This study found that both ciclosporin A and topical therapy were effective in reducing alopecia and scaling in dogs with idiopathic sebaceous adenitis, with evidence suggesting improved outcomes when both treatments are combined.

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Learn

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learn Glycerin

Can glycerin be used in combination with active ingredients like minoxidil or tretinoin? Glycerin is a common humectant that formulators treat as compatible with topical actives, but no published trial has tested it alongside minoxidil or tretinoin, so any benefit is comfort rather than a proven effect. Tretinoin is prescription-only and carries pregnancy warnings.
Does topical glycerin have any effect on hair thickness or follicle function? Topical glycerin primarily hydrates hair but does not increase thickness or follicle function.

learn sh-Polypeptide-7

learn Finasteride

Topical or oral? Choosing between pills and lotions according to your case. Topical finasteride offers localized treatment with fewer systemic side effects than oral finasteride.

learn Cetirizine

Is topical cetirizine effective for androgenetic alopecia in women? Topical cetirizine is not an approved product and its use for female-pattern hair loss is off-label. The evidence is one small unblinded pilot study in mixed-sex patients and one randomized trial in 66 women where cetirizine was added to minoxidil; it is unproven on its own.

learn Estradiol

How does topical Estradiol compare to oral Estradiol in treating alopecia? Topical estradiol delivers hormone to the scalp with less systemic exposure, but evidence is thin and it is still a hormone. It needs a doctor's supervision, and people with estrogen-sensitive cancers must not use it without medical approval.

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