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research Clinical Study to Evaluate Safety and Efficacy of a Topical Hair Minimizing Lotion in Healthy Human Volunteers

1 citations , January 2017 in “Journal of Clinical Trials & Patenting”

This study assessed the safety and efficacy of Romantaque lotion for unwanted hair growth and found statistically significant hair growth inhibition with no adverse effects in 30 volunteers after repeated applications over one year.

Topical Formulations Containing Finasteride: In Vitro Permeation/Penetration Study and In Vivo Pharmacokinetics in Hairless Rat

research Topical Formulations Containing Finasteride. Part I: In Vitro Permeation/Penetration Study and In Vivo Pharmacokinetics in Hairless Rat

23 citations , June 2014 in “Journal of Pharmaceutical Sciences”

This study found that the HPCH-based formulation P-08–016 may facilitate finasteride deposition in the dermis, potentially offering an alternative to systemic therapy by minimizing systemic absorption.

research Topical Metformin In Dermatology: A Narrative Review Of Efficacy And Formulation Approaches

December 2025 in “MEDFARM Jurnal Farmasi dan Kesehatan”

This review evaluates existing research on topical metformin for skin conditions, reporting promising outcomes such as improved wound healing, melasma, psoriasis, acne, and alopecia, with innovative formulations like hydrogels and lipid nanoparticles enhancing its cutaneous delivery while minimizing systemic exposure.

research Optimal Management of Hair Loss (Alopecia) in Children

49 citations , January 2003 in “American Journal of Clinical Dermatology”

This review discusses various pediatric hair loss conditions and treatments, highlighting the importance of a holistic approach and noting that no single treatment is universally effective.

research Trigonelline nanocrystal-based topical creams for the treatment of hair loss

October 2024 in “Journal of Advanced Pharmaceutical Technology amp Research”

This study found that nanoparticulate trigonelline formulations significantly improved hair length and density in rats with induced alopecia compared to controls and commercial hair oil, though it was not more effective than minoxidil after 30 days.

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Community Join

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community Topical Metformin for Hair Transplant donor area skin/hair regeneration?

4 upvotes 1 year ago

Topical Metformin shows potential for regenerating hair follicles and minimizing scarring in hair transplant donor areas, similar to Verteporfin but without its side effects. The discussion suggests considering Metformin for post-hair transplant care, though more human trials are needed.

community M25: Getting way too many DMs, so let’s do this here! AMA about Male Pattern Baldness, Hair Loss, and Products (100% Science-Backed )

1951 upvotes 5 months ago

Finasteride, dutasteride, and minoxidil are discussed as treatments for male pattern baldness. Finasteride and dutasteride are effective DHT blockers, while minoxidil is necessary for regrowth but must be used consistently.

community Comprehensive Microneedling Guide

292 upvotes 4 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

community Minimizing systemic DHT reduction with topicals

5 upvotes 4 weeks ago

The conversation discusses minimizing systemic DHT reduction using topical treatments for hair loss, specifically mentioning Minoxidil, Finasteride, and a proprietary carrier for DUT by XYON Health. The focus is on finding effective DHT blockers with minimal systemic absorption.

community Essential hair oils and other methods to maximise hair growth

3 upvotes 11 months ago

The conversation is about maximizing hair growth using treatments like oral finasteride, topical minoxidil, caffeine and ketoconazole shampoos, biotin, omega-3, vitamin D supplements, microneedling, and various hair oils such as rosemary, castor, coconut, and peppermint. Users discuss the effectiveness of these methods and share personal experiences with hair oils for scalp health and hair maintenance.

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Learn

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learn Overview

learn Fluridil

a topical anti-androgen with less systemic involvement

learn Microneedling

technique to create small wounds in skin to activate collagen production and hair growth

learn Alfatradiol

a synthetic estrogen used topically as an anti-androgen

learn Glycerin

Does topical glycerin have any effect on hair thickness or follicle function? Topical glycerin primarily hydrates hair but does not increase thickness or follicle function.

learn L-cysteine

Can topical products with L-cysteine repair damaged hair or prevent breakage? Topical L-cysteine cannot effectively repair damaged hair or prevent breakage.

learn Rapamycin

Does topical rapamycin actually help reactivate dormant hair follicles? Topical rapamycin may help reactivate dormant hair follicles, but evidence is still emerging.

learn Vitamin B12

Can topical products containing Vitamin B12 improve scalp health and hair growth? Topical Vitamin B12 may not significantly improve hair growth unless there's a deficiency.

learn Vitamin C

Is topical Vitamin C effective for scalp and hair growth? Topical Vitamin C may help improve scalp health but lacks strong evidence for hair growth.

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