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research Successful management of severe alopecia areata and vitiligo using topical delgocitinib and a 308-nm excimer laser

August 2023 in “European journal of dermatology/EJD. European journal of dermatology”

This study reported that therapeutic make-up significantly improves the long-term quality of life for patients with facial dermatoses, showing a sustained benefit one year after application, particularly in younger patients.

research Randomized Controlled Trial of the Topical Jak Inhibitor Delgocitinib Cream in Patients with Frontal Fibrosing Alopecia

1 citations , October 2025 in “Journal of Investigative Dermatology”

In this study of women with frontal fibrosing alopecia, delgocitinib cream improved the molecular signature of lesions and demonstrated potential as a treatment, showing significant transcriptomic changes and some clinical improvements over 12 weeks compared to a cream vehicle.

research Comparative efficacy and safety of JAK inhibitors in the treatment of moderate-to-severe alopecia areata: a systematic review and network meta-analysis

April 2024 in “Frontiers in pharmacology”

This study compared JAK inhibitors for moderate-to-severe alopecia areata and found brepocitinib 30mg and deuruxolitinib 12mg to be most effective, though deuruxolitinib may cause more adverse events. Further research is needed for long-term efficacy and safety.

research Emerging Topical and Systemic JAK Inhibitors in Dermatology

277 citations , December 2019 in “Frontiers in Immunology”

This review discusses the immunological basis and development of Janus kinase inhibitors for treating skin diseases and reports no new clinical findings.

research Janus Kinase inhibitors in dermatology: a review

1 citations , January 2023 in “Portuguese Journal of Dermatology and Venereology”

This review covers the use of JAK inhibitors in treating various dermatological conditions, emphasizing their potential while noting ongoing safety concerns with oral treatments; no new clinical results are provided.

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Community Join

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community Topical minoxidil routine and shampooing frequency

4 upvotes 4 days ago

The user applies 10% minoxidil nightly, takes 1mg finasteride, multivitamins, and a hair growth serum, and is concerned about over-washing hair with dermatologist-recommended shampoo. It is suggested to shampoo every other day and rinse with water on alternate days unless otherwise advised by a dermatologist.

community Topical min 13 months and oral fin 6 months, progress

11 upvotes 5 days ago

The user has been using topical minoxidil for 13 months and oral finasteride for 6 months to address hair loss after a hair transplant. They plan to switch to oral minoxidil for better results and occasionally use topical minoxidil and microneedling.

community F23 does Topical Min work on vellus hairs?

in Female 72 upvotes 6 days ago

Topical minoxidil 5% may help turn vellus hairs into normal-looking hairs, but results can vary, especially on the temples. The user stopped testosterone injections and finasteride, which may have affected hair recovery.

community Topical dutasteride + minox + oral fin 1mg/day

7 upvotes 6 days ago

The conversation discusses hair regrowth using topical dutasteride, minoxidil, and oral finasteride 1mg/day. The user reports seeing new hair growth.

community Topical Tacrolimus For Androgenetic Alopecia (AGA)

6 upvotes 1 week ago

Topical tacrolimus is being considered for androgenetic alopecia, though its effectiveness is unproven. Other treatments mentioned include minoxidil, dutasteride, cyclosporine, and teicoplanin, with discussions on blocking the prolactin receptor for hair growth.

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Learn

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learn Finasteride

Topical or oral? Choosing between pills and lotions according to your case. In studies, topical finasteride gave much lower blood levels of the drug than tablets but still lowered blood DHT, and whether it causes fewer side effects has not been established. There is no FDA-approved topical finasteride, and the FDA warned about compounded versions in April 2025.

learn Cetirizine

Is topical cetirizine effective for androgenetic alopecia in women? Topical cetirizine is not an approved product and its use for female-pattern hair loss is off-label. The evidence is one small pilot study in mixed-sex patients and one randomized trial in 66 women where cetirizine was added to minoxidil; it is unproven on its own.

learn Glycerin

Does topical glycerin have any effect on hair thickness or follicle function? Topical glycerin mainly hydrates the hair and scalp; no study has shown that it increases hair thickness or changes follicle function.

learn Valproic acid

How is valproic acid being explored differently in topical hair products compared to its traditional oral medical use? Topical valproic acid is being studied for local effects on the hair follicle rather than the whole-body effects of the oral drug. The human evidence is one small randomized 24-week trial of an 8.3% spray; no topical valproate product is approved for hair loss.

learn Vitamin B12

Can topical products containing Vitamin B12 improve scalp health and hair growth? Topical Vitamin B12 may not significantly improve hair growth unless there's a deficiency.

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