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GlossaryThyroid Hormone Receptors

proteins in cells that bind thyroid hormones to regulate genes

Thyroid Hormone Receptors (THRs) are proteins found in cells that bind to thyroid hormones, which are crucial for regulating metabolism, growth, and development. When thyroid hormones attach to these receptors, they influence the expression of specific genes, thereby affecting various physiological processes. This interaction is essential for maintaining normal metabolic function and can impact conditions like alopecia if disrupted.

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Thyroid Hormones and Androgens Differentially Regulate Gene Expression in Testes and Ovaries of Sexually Mature Silurana Tropicalis

research Thyroid Hormones and Androgens Differentially Regulate Gene Expression in Testes and Ovaries of Sexually Mature Silurana Tropicalis

13 citations, July 2018 in “General and comparative endocrinology”

Thyroid hormones and androgens affect gene expression in frog reproductive organs differently between males and females.

research Triclocarban, Triclosan, Bromochlorophene, Chlorophene, and Climbazole Effects on Nuclear Receptors: An In Silico and In Vitro Study

29 citations, October 2020 in “Environmental health perspectives”

Five preservatives may disrupt hormone function and need more health and environmental risk assessment.

research Molecular Genetic and Endocrine Mechanisms of Hair Growth

51 citations, January 2003 in “Hormone Research in Paediatrics”

Hormones and their receptors, especially androgens, play a key role in hair growth and disorders like baldness.

research Thyroid Receptor β: A Promising Target for Developing Novel Anti-Androgenetic Alopecia Drugs

May 2024 in “Drug discovery today”

Thyroid receptor β can help develop new drugs to treat hair loss.

research Non-Canonical Dimerization of the Androgen Receptor and Other Nuclear Receptors: Implications for Human Disease

25 citations, June 2019 in “Endocrine Related Cancer”

Mutations in certain receptors can cause diseases and offer new treatment options.

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community Phase II Clinical Trial for TDM-105795 started recruiting

in Research/Science 23 upvotes 1 year ago

A Phase II clinical trial for TDM-105795 has started recruiting in the US, and it might be a promising treatment for hair loss. Many hair loss drugs, including this one, originate from China.

community Phase II for Technoderma Therepeutic's TDM-105795 set to begin in April tentatively

in Research/Science 41 upvotes 1 year ago

Phase II for TDM-105795 for Androgenic Alopecia is set to begin in April 2023. The study aims to evaluate the efficacy and safety of TDM-105795 in male subjects.

community TDM-105795, a new hair loss treatment that actually works!

in Treatment 44 upvotes 1 year ago

A new hair loss treatment called TDM-105795 is discussed as a potential replacement or add-on to Minoxidil. Users express hope for new effective treatments.

community Update of my case, might have finally found what happened

in Minoxidil 6 upvotes 5 months ago

OP believes RU58841 affected their thyroid, causing hypothyroidism and impacting minoxidil's effectiveness. They plan to start thyroid medication to improve hair regrowth.

community My Experience and a Discourse on "DUPA"

in Treatment 8 upvotes 9 months ago

The user discusses their hair loss experience, exploring various hypotheses including thyroid levels, vitamin D, DHEA, nutritional deficiency, diabetes, seborrheic dermatitis, lack of nutrition to hair follicles, chronic inflammation, female pattern hair loss causes, cortisol, and prolactin levels. They are currently using finasteride, beta-sitosterol, and have tried topical dutasteride and microneedling therapy.

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