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This study demonstrates that canonical Wnt signaling is crucial for maintaining thymic epithelial microenvironments in postnatal thymus, possibly by affecting TEC progenitor cells.

This case report describes a 22-year-old woman who developed persistent, non-scarring hair loss and premature ovarian failure following a myeloablative umbilical cord transplant for acute myeloid leukemia.

This study found that deleting the ATR gene in adult mice led to rapid onset of age-related traits such as hair graying and osteoporosis through reduced regenerative capacity.

This study found that mesenchymal cells from different organs exhibit substantial heterogeneity, with thymic mesenchymal cells particularly adapted for interacting with epithelial and hematolymphoid cells in high-apoptosis environments.

This study reported that in mice with rapamycin-induced thymic atrophy, Angelica sinensis promoted thymic cortical regeneration and functional recovery by activating the Wnt/CTNNB1/Foxn1 signaling pathway and improving inflammatory microenvironment, suggesting its potential benefit against immune aging.