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research Age-Dependent Loss of the Stemness and Antimicrobial Defense Function of Dermal Fibroblasts Is Mediated by TGFbeta

April 2018 in “Journal of Investigative Dermatology”

Aging reduces skin cell renewal and defense against germs due to TGFbeta, but blocking TGFbeta could help restore these functions.

research Age-Related Loss of Innate Immune Antimicrobial Function of Dermal Fat Is Mediated by Transforming Growth Factor Beta

96 citations, December 2018 in “Immunity”

Targeting TGFβ can improve skin immunity in older people.

research Mechanism of Action of Herbs and Their Active Constituents Used in Hair Loss Treatment

47 citations, August 2016 in “Fitoterapia”

Some herbs and their components might help treat hair loss by affecting various biological pathways, but more research and regulation are needed.

research Molecular Biology of Hair Morphogenesis: Development and Cycling

155 citations, August 2003 in “Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution”

Understanding hair growth involves complex interactions between molecules and could help treat hair disorders.

research Friends Turned Foes: Angiogenic Growth Factors Beyond Angiogenesis

24 citations, October 2017 in “Biomolecules”

Some growth factors, while important for normal body functions, can cause diseases when not regulated properly.

View more "tgfbr inhibitors" in research →

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community HLT Megathread on HMI-115 (key takeaways in comments)

in Research/Science 39 upvotes 2 years ago

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

community Opinions on Scalp fibrosis and DHT?

in Research/Science 9 upvotes 3 years ago

The conversation discusses the theory that scalp fibrosis contributes to male pattern baldness (MPB) by increasing DHT concentration, and mentions treatments like Minoxidil. The user seeks opinions on the theory and the effectiveness of scalp massages.

community Group Buy for MR antagonist finerenone

in Product 11 upvotes 2 years ago

User discusses group buy for finerenone, a third-gen mineralocorticoid antagonist for hair loss treatment. Finerenone inhibits TGFb, NOX, and ROS, and improves renal and cardiac function; topical dose should be no more than 10mg per day.

community Hair loss causes are still a myth.

in Chat 16 upvotes 3 years ago

The conversation discusses the complexity of hair loss causes, suggesting that DHT sensitivity alone doesn't fully explain it. Treatments mentioned include finasteride and dutasteride.

community Had anyone used peptides for help with regrowth?

in Treatment 7 upvotes 2 weeks ago

Peptides like GHK-Cu are discussed for hair regrowth, with mixed results; some users report no regrowth, while others notice thicker hair. Topical application is common, and proper sourcing and mixing are emphasized.