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Sexually Dimorphic Effect of Progesterone and Its Reduced Metabolites on the Gene Expression of Myelin Proteins in Rat Schwann Cells

research Sexually Dimorphic Effect of Progesterone and Its Reduced Metabolites on the Gene Expression of Myelin Proteins in Rat Schwann Cells

May 2006 in “Frontiers in Neuroendocrinology”

Progesterone and its metabolites affect myelin protein expression differently in male and female rat Schwann cells.

research Isotope Dilution-Based Targeted and Nontargeted Carbonyl Neurosteroid/Steroid Profiling

12 citations, March 2018 in “Analytical chemistry”

Researchers created a new method to measure brain steroids, finding higher levels of certain steroids and changes due to a drug.

research A New Look at the 5-Alpha-Reductase Inhibitor Finasteride

137 citations, March 2006 in “Cns Drug Reviews”

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

research Neurosteroids, Neuroactive Steroids, and Symptoms of Affective Disorders

82 citations, August 2006 in “Pharmacology, Biochemistry and Behavior”

Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.

Neuroactive Steroid Levels Are Modified in Cerebrospinal Fluid and Plasma of Post-Finasteride Patients Showing Persistent Sexual Side Effects and Anxious/Depressive Symptomatology

research Neuroactive Steroid Levels Are Modified in Cerebrospinal Fluid and Plasma of Post-Finasteride Patients Showing Persistent Sexual Side Effects and Anxious/Depressive Symptomatology

73 citations, July 2013 in “The Journal of Sexual Medicine”

Finasteride use changes brain chemicals, causing lasting sexual issues and anxiety/depression.

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community 18M 8 months progress 40mg daily dut stack

in Progress Pictures 113 upvotes 3 weeks ago

An 18-year-old is using a high-dose hair loss treatment with 40mg daily dutasteride, finasteride, minoxidil, tretinoin, and topical bicalutamide. Despite health risk concerns, especially liver issues, they report hair regrowth progress and intend to continue the regimen.

community I've been afflicted by post finasteride syndrome, what now?

in Finasteride 42 upvotes 6 years ago

A user experienced severe side effects from finasteride, including mental health issues and physical symptoms, and sought advice on managing post-finasteride syndrome. Suggestions included checking vitamin levels, considering dopamine agonists, and avoiding further psychiatric medications.