research In vivo and in vitro effect of novel 4,16-pregnadiene-6,20-dione derivatives, as 5α-reductase inhibitors
The new compounds may be more effective and cheaper than current treatments for conditions like baldness.
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research Evaluation of New Pregnane Derivatives as 5.ALPHA.-Reductase Inhibitor.
This study found that several synthesized pregnane derivatives exhibited significant inhibitory effects on testosterone conversion to dihydrotestosterone and reduced related androgenic parameters in multiple pharmacological models.
research Curcumin derivatives inhibit testicular 17β-hydroxysteroid dehydrogenase 3
This study evaluated curcumin analogues as potential inhibitors of 17β-HSD3 in rat and human models, but it does not report new clinical findings.
research Androgenic and anti-androgenic effects of progesterone derivatives with different halogens as substituents at the C-6 position
This study found that compound 10 inhibited testosterone conversion to DHT in hamster flank organs and seminal vesicles, whereas compound 11's inhibitory effect varied with dose, linked to halogen electronegativity differences.
research Synthesis and Pharmacological Evaluation of New 16-Methyl Pregnane Derivatives.
This study found that several new pregnane derivatives, especially steroids 16 and 19, demonstrated higher antiandrogenic activity on male hamster models than the commonly used finasteride.
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5 / 1000+ resultscommunity Can testosterone alone cause hair loss even after nuking DHT?
Testosterone can still cause hair loss even when DHT is blocked by dutasteride, especially if hair follicles are sensitive. Topical treatments like RU58841 or pyrilutamide may help, but their long-term effectiveness is uncertain compared to dutasteride.
community Testosterone and Estradiol levels on 1 mg/day dutasteride
A 30-year-old man experienced significant hair regrowth and improved libido after using finasteride and dutasteride for androgenetic alopecia, with no adverse effects. He plans to reduce dutasteride dosage when trying to conceive and has been using topical minoxidil since 2015.
community Testosterone's Role In Androgenetic Alopecia
DHT is essential for androgenetic alopecia, not testosterone. Treatments like finasteride and dutasteride reduce DHT, halting hair loss.
community Testosterone and hair loss seeming irrelevance
The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.
community Ray Peat: Testosterone Isn’t the Culprit, Prolactin and Cortisol Drive Hair Loss (2016)
Prolactin and cortisol are identified as key factors in hair loss, with stress hormones impacting hair shedding. Finasteride and minoxidil are effective treatments, while DHT's role and individual sensitivity are significant factors.
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6 / 801 results- Could bicalutamide help trans women regrow hair lost to testosterone? No study has tested bicalutamide for hair regrowth in trans women. In cisgender women the only randomized trial found it added nothing to minoxidil, and it is an off-label prescription drug that requires liver monitoring.
learn Cyproterone
a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor
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learn GT20029
research compound made to degrade androgen receptors in scalp
learn RU58841
a potent but unapproved and potentially problematic topical anti-androgen
learn Alfatradiol
a synthetic estrogen used topically as an anti-androgen
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6 / 15 results- 35Hair Loss TreatmentsTestosterone ReplacementPlantation, FL · US
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- 10Hair Loss TreatmentsReady Testosterone and Men's Health ClinicHouston, TX · US
- 23Hair Loss TreatmentsSoCal Testosterone ClinicLos Angeles, CA · US
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