July 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”
This study found that back skin mesenchyme from mouse embryos can induce hairfollicle formation even before dermal condensate formation, but R-spondin-1 alone or with a Bmp receptor inhibitor was not sufficient for hairfollicleinduction.
This study suggests that skin-derived precursors from Sox2(+) hairfollicle dermal cells have the potential to function as dermal stem cells, supporting hair morphogenesis, dermal maintenance, and wound-healing.
In this study, researchers observed that fasting-induced molting in laying hens led to increased thyroid hormones, which may regulate feather molting by affecting hairfollicle growth through specific signaling pathways, highlighting molecular changes during induced molting.
Creatine does not cause hair loss, despite many users reporting personal experiences of hair shedding. Scientific evidence shows no link between creatine and increased hair loss or hormone changes.
PP405 is criticized for overhyped claims and cherry-picked data, with doubts about its effectiveness compared to minoxidil and finasteride. Many users express skepticism, emphasizing the need for more comprehensive trial results.
To minimize hair loss while using steroids, use finasteride or dutasteride and apply topical anti-androgens like RU58841. Avoid high doses of hair-toxic steroids; prefer testosterone, nandrolone, and boldenone.
The user shaved their head and noticed some hair regrowth and thickening due to Minoxidil and finasteride. They are content with their hair loss and have accepted it, while also observing that others don't notice the thinning as much as they do.
How does SCUBE3 work on hair follicles compared to treatments like minoxidil or finasteride?Laboratory research in mice reports that SCUBE3, a protein released by dermal papilla cells, signals dormant follicles to grow through the TGF-β pathway downstream of Hedgehog; minoxidil and finasteride instead work on blood flow to the follicle and on DHT, and unlike SCUBE3 they have decades of human trial data behind them. SCUBE3 has not been tested in human clinical trials and is not available as a medicine.