November 2024 in “Journal of the European Academy of Dermatology and Venereology” In this pilot study, cryotherapy using a device that precisely controls cooling duration improved hair regrowth for patchy alopecia areata when applied for 20 seconds with two freeze-thaw cycles, similar to standard triamcinolone acetonide injections, but not when applied for 10 seconds.
January 2025 in “Journal of the Egyptian Womenʼs Dermatologic Society” In this study, both fractional carbon dioxide laser therapy and cryotherapy were found to be effective and safe for treating patchy alopecia areata, showing similar efficacy in improving hair growth compared to untreated control patches.
This study tested a novel cryo-carboxy dispensing device for treating androgenetic alopecia in six volunteers and found an unexpectedly rapid and positive response, with significant hair regrowth observed by day 90, prompting early conclusion of the trial.
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January 2020 in “Acta Dermatovenerologica Alpina Pannonica et Adriatica” Cryotherapy is effective for ingrown toenails, especially in single cases, but has high recurrence in younger and bilateral cases.
January 2026 in “Dermatology Practical & Conceptual” In a systematic review and meta-analysis, the researchers found that intralesional triamcinolone acetonide was more effective than cryotherapy for achieving significant hair regrowth in patients with patchy alopecia areata, although both treatments had distinct safety profiles.