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GlossaryTaxane-based chemotherapy

involves drugs that prevent cancer cell division

Taxane-based chemotherapy, also known as Taxane treatment, involves the use of drugs derived from the yew tree, such as paclitaxel and docetaxel, to treat various cancers. These drugs work by stabilizing microtubules in cancer cells, preventing them from dividing and leading to cell death. This type of chemotherapy is commonly used for breast, ovarian, and lung cancers, but it can also cause side effects like hair loss (alopecia) and neuropathy.

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research Dermatological Adverse Events with Taxane Chemotherapy

141 citations, September 2016 in “European Journal of Dermatology”

Taxane chemotherapy can cause skin, hair, and nail side effects, which are often under-reported and can affect patient quality of life.

Permanent Alopecia in Patients with Breast Cancer After Taxane Chemotherapy and Adjuvant Hormonal Therapy: Clinicopathologic Findings in a Cohort of 10 Patients

research Permanent Alopecia in Patients with Breast Cancer After Taxane Chemotherapy and Adjuvant Hormonal Therapy: Clinicopathologic Findings in a Cohort of 10 Patients

31 citations, March 2017 in “Journal of The American Academy of Dermatology”

Some breast cancer patients developed permanent hair loss after chemotherapy and hormonal therapy, showing patterns similar to common baldness and alopecia areata.

Persistent Alopecia in a Breast Cancer Patient Following Taxane Chemotherapy and Adjuvant Endocrine Therapy: Case Report and Review of Post-treatment Hair Loss in Oncology Patients with Breast Cancer

research Persistent Alopecia in a Breast Cancer Patient Following Taxane Chemotherapy and Adjuvant Endocrine Therapy: Case Report and Review of Post-treatment Hair Loss in Oncology Patients with Breast Cancer

3 citations, July 2018 in “Cureus”

A breast cancer patient had lasting hair loss after chemotherapy, which improved with minoxidil treatment.

research Safety, Tolerability, and Pharmacokinetics of Topical Calcitriol Formulation for Treatment of Chemotherapy-Induced Alopecia in Patients Receiving Taxane-Based Regimen: Final Results

May 2019 in “Journal of clinical oncology”

Topical calcitriol was safe and well-tolerated for potential hair loss prevention in chemotherapy patients.

research Permanent Chemotherapy-Induced Alopecia in Patients with Breast Cancer: A 3-Year Prospective Cohort Study

59 citations, August 2018 in “The oncologist”

Some breast cancer patients still experience hair loss three years after chemotherapy, especially with taxane-based treatments.

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