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research Frontal fibrosing alopecia shows robust T helper 1 and Janus kinase 3 skewing

34 citations , June 2020 in “British journal of dermatology/British journal of dermatology, Supplement”

In this study, researchers observed that follicular damage and stem cell loss in frontal fibrosing alopecia may be mediated by immune attacks at the bulge region, suggesting potential for JAK/STAT-targeting treatments to prevent progression.

research Study shows thicker hair isn’t necessarily stronger

December 2019 in “C&EN Global Enterprise”

This study found that the internal structure and fracture patterns of hair vary among different mammal species, which could inform the development of keratin-based biomaterials for medical and cosmetic applications.

research 264 CCR5 blockade shows prevention of alopecia areata development as well as improvement of alopecia areata

September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that orally administering the CCR5 inhibitor Maraviroc improved hair loss in 4 out of 5 mice with alopecia areata and also reduced the development of the condition, evidenced by decreased CCR5+ T-cell infiltration in treated mice.

research 572 Development of immunotherapies targeting TCR-Vβ2 for treatment of cutaneous T cell lymphoma

July 2024 in “Journal of Investigative Dermatology”

Targeting TCR-Vβ2 in cutaneous T cell lymphoma shows promise for safer, more specific treatment.

research Effects of Shoot Length on Amounts of Functional Components of Leaves and Shoots for Tea from Japanese Persimmon 'Saijo'

5 citations , January 2006 in “food preservation science”

The study concludes that shoots and leaves of Japanese persimmon 'Saijo' contain high levels of total ascorbic acid and polyphenols, making them suitable for health foods, with foliating leaves offering the highest polyphenol content.

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community Diffuse thinner - How to cosmetically increase the thickness of your hair strands themselves when you don't have bald spots?

6 upvotes 1 year ago

To increase hair density appearance, options include using hair fibers, volume powders, scalp micropigmentation, and a combination of sea salt and holding sprays. Tape-in extensions and clip-in fringes are also considered, but cost and maintenance are concerns.

community Wouldn’t it be funny if there already was a drug that existed which reactivated sleeping follicles? It would be our own version of Ozempic

202 upvotes 1 year ago

PP405 shows promise for reactivating hair follicles, with potential maintenance using 5AR inhibitors. Current treatments like Minoxidil and finasteride are effective but have limitations, and there is hope for more effective solutions in the future.

community If PP405 doesn't work then why would Pelage continue with trials?

44 upvotes 1 month ago

PP405 is still undergoing trials despite skepticism about its effectiveness. Some believe it shows potential for hair regrowth, possibly in combination with other treatments like minoxidil or finasteride, while others are doubtful due to past disappointments with similar products.

community Creatine Doesn’t Cause Hair Loss: Stop the BS

137 upvotes 11 months ago

Creatine does not cause hair loss, despite many users reporting personal experiences of hair shedding. Scientific evidence shows no link between creatine and increased hair loss or hormone changes.

community Rooney is actually a great example of why fin doesn’t “save” everyone

102 upvotes 8 months ago

Finasteride, minoxidil, and dutasteride can slow hair loss but aren't effective for everyone, especially with aggressive hair loss. Wayne Rooney's case shows treatments and transplants may not prevent hair loss due to genetics.

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Learn

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learn Omega 3

Can a shampoo with omega-3s help thicken those early thinning spots? Shampoos with omega-3s may improve scalp health but won't thicken hair directly.

learn Metformin

diabetes drug with anti-inflammatory, immunomodulatory, and insulin-sensitizing properties

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Overview

learn Dutasteride

Dutasteride: Why don't some doctors prescribe it if it's stronger than finasteride? Some doctors avoid prescribing dutasteride due to its higher risk of side effects.

learn Scalp Micropigmentation

Why can't I see my scalp micropigmentation after a week? Initial fading of scalp micropigmentation is normal and density improves with subsequent sessions.

learn Hair Transplant

What happens if I don't have enough donor hair for a hair transplant? Body hair or beard hair can be used if scalp donor hair is insufficient.

learn Centella

Ever wonder why your hair doesn’t grow back thick anymore? Maybe your scalp needs better blood flow: centella could help. There is no clinical trial of centella asiatica for hair loss and no study measuring scalp blood flow in people using it; the only hair-related evidence is a 2017 cell-culture study. Centella products are cosmetics that may soothe an irritated scalp, and the link between scalp circulation and pattern hair loss is itself unproven.

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