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research Update on the dermatologic use of systemic glucocorticosteroids

40 citations , July 2007 in “Dermatologic Therapy”

This review discusses the pharmacologic properties, mechanisms, dosing options, and adverse effects of systemic glucocorticosteroids in dermatology, but reports no new findings.

research European expert consensus statement on the systemic treatment of alopecia areata

4 citations , January 2024 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

This consensus statement outlines a treatment algorithm for alopecia areata, detailing systemic treatment indications and options, including EMA-approved medications baricitinib and ritlecitinib for severe cases, as well as other off-label treatments and adjuvant therapies like oral minoxidil.

research PRIDE syndrome associated with panitumumab treatment – case report and literature review

1 citations , January 2023 in “Przegląd Dermatologiczny”

This case report describes a 64-year-old man with advanced colorectal cancer developing cutaneous side effects from panitumumab, highlighting the importance of early diagnosis and treatment to improve quality of life and therapy continuation.

research Necrobiosis lipoidica of the scalp

September 2023 in “Russian Journal of Skin and Venereal Diseases”

This study reported a rare case of necrobiosis lipoidica occurring on the scalp, leading to scarring alopecia, and highlighted a positive response to glucocorticoid therapy by reducing the brightness and growth of plaques over one month.

research Cutaneous lupus erythematosus. Diagnostic and therapeutic recommendations of the Polish Dermatological Society

January 2018 in “Przegla̧d dermatologiczny”

This article presents diagnostic and therapeutic recommendations for cutaneous lupus erythematosus from the Polish Dermatological Society, but reports no new clinical findings.

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learn Prednisolone

learn Hydrocortisone

a synthetic cortisol used for anti-inflammatory effects

learn Follistatin

Can follistatin be applied topically, or is it only effective through injections or systemic use? Follistatin is not effective when applied topically and requires injections or systemic use.

learn Thymosin Beta 4

Is Thymosin Beta 4 being explored more as a topical treatment or as a systemic (oral or injectable) approach for hair loss? Thymosin Beta 4 is primarily being explored as a topical treatment for hair loss.

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Community Join

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community Non-systemic hair loss stack, is there any hope?

6 upvotes 3 weeks ago

A 19-year-old is experiencing hair thinning and has tried various doses of oral and topical finasteride but faced psychological and sexual side effects. They are considering topical anti-androgens like KX826, ketoconazole cream, and RU58841 as alternatives, while others suggest clascoterone and topical dutasteride.

community Minimizing systemic DHT reduction with topicals

5 upvotes 4 weeks ago

The conversation discusses minimizing systemic DHT reduction using topical treatments for hair loss, specifically mentioning Minoxidil, Finasteride, and a proprietary carrier for DUT by XYON Health. The focus is on finding effective DHT blockers with minimal systemic absorption.

community Has any data on systemic absorption of pyrilutamide been published?

1 upvotes 4 months ago

Pyrilutamide shows minimal systemic absorption with low plasma levels and no accumulation, suggesting it's unlikely to cause systemic side effects. However, full results are not yet published in scientific journals.

community Any treatment not nuking systemic DHT levels?

16 upvotes 6 months ago

Hair loss treatments that avoid significantly lowering systemic DHT levels, focusing on topical options like dutasteride mesotherapy, minoxidil, and ketoconazole. The user is exploring alternatives like KX-826 and RU58841 due to concerns about hormone levels.

community Are we underestimating systemic absorption with homemade/generic Topical Fin? (HPCH vs. PG/Ethanol formulations)

5 upvotes 7 months ago

Topical finasteride may have higher systemic absorption and lower efficacy when using a Propylene Glycol/Ethanol formulation compared to the hydroxypropyl chitosan (HPCH) formulation. The safety profile of topical finasteride relies heavily on the HPCH formulation, and using standard solutions might lead to different pharmacokinetics.

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