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research Scalp biopsy identifies systemic amyloidosis presenting as isolated telogen effluvium: A case report

January 2019 in “SAGE Open Medical Case Reports”

This paper reports a rare case where AL amyloidosis presented as isolated scalp alopecia, underscoring the importance of considering systemic amyloidosis in the differential diagnosis of alopecia.

research Skin diseases associated with Agent Orange and other organochlorine exposures.

April 2016 in “Journal of The American Academy of Dermatology”

Certain skin diseases are linked to Agent Orange and similar chemicals; veterans should be screened and informed about uncertain risks, and current data doesn't link spironolactone with breast cancer.

research Skin fragility, diffuse ecchymosis and blisters on a yellowish waxy base

April 2016 in “Journal of The American Academy of Dermatology”

A woman's skin symptoms led to a diagnosis of systemic AL amyloidosis, but she died from sepsis shortly after.

research Amyloid-Associated Alopecia: A Reappraisal Including Its Pathophysiology

6 citations , March 2019 in “The American Journal of Dermatopathology”

This report describes three cases of LC-associated amyloidosis presenting with alopecia, highlighting its potential mimicry of androgenetic alopecia or alopecia areata without systemic amyloidosis.

research Mice with Alopecia, Osteoporosis, and Systemic Amyloidosis Due to Mutation in Zdhhc13, a Gene Coding for Palmitoyl Acyltransferase

73 citations , June 2010 in “PLoS Genetics”

This study identified that a deficiency in the palmitoyl transferase enzyme, due to a mutation in the Zdhhc13 gene, led to severe physiological abnormalities in mice, including skin, bone, and systemic amyloid issues.

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community Would a combination of low dose oral and topical finasteride theoretically give the best outcome?

in Finasteride/Dutasteride 5 upvotes 4 months ago

Using a combination of low-dose oral and topical finasteride, along with minoxidil, may effectively manage hair loss by targeting both systemic and local DHT. Users report positive experiences with this regimen, noting good tolerability and no worsening of hair condition.

community How is there still no consensus on Topical Dutasteride in 2024?

in Finasteride/Dutasteride 147 upvotes 2 years ago

The conversation expresses frustration over the lack of clear evidence regarding the effectiveness and systemic impact of topical Dutasteride for hair loss treatment, despite years of discussion. People are criticized for not conducting proper research and for providing contradictory anecdotal claims.

community A Nuanced Look at Microdosing Topical Finasteride

86 upvotes 2 years ago

The conversation discusses using a low dose of topical finasteride to achieve hair benefits with minimal systemic exposure. Users share experiences and opinions on dosing, systemic buildup, and side effects of both topical and oral finasteride.

community Topical Dutasteride Seems to Work

in Research/Science 22 upvotes 10 months ago

Topical dutasteride, particularly at 0.05%, shows greater hair density improvement than oral finasteride over 24 weeks, though hair thickness gains are similar. Some users report side effects with topical treatments, but others find them effective for maintaining hair without significant systemic absorption.

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