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Local Synthesis and Function of Neuro-Estrogen and Neuro-Androgen: Impact on Hippocampus-Related Cognition and Neuronal Plasticity

research Local synthesis and function of neuro-estrogen and neuro-androgen: impact on the hippocampus-related cognition and neuronal plasticity

January 2026 in “Frontiers in Cellular Neuroscience”

This study discusses the complex roles and effects of brain-synthesized sex neurosteroids, highlighting sex differences in their concentrations and their varied impacts on synaptic plasticity, cognitive behavior, and aging-related cognitive decline.

research Neo-synthesis of estrogenic or androgenic neurosteroids determine whether long-term potentiation or depression is induced in hippocampus of male rat

32 citations , October 2015 in “Frontiers in Cellular Neuroscience”

This study found that in male rat hippocampal slices, DHT is necessary for low frequency stimulation-induced long-term depression, while E2 synthesis is essential for high frequency stimulation-induced long-term potentiation.

research Estrogen regulates the expression of retinoic acid synthesis enzymes and binding proteins in mouse skin

3 citations , August 2021 in “Nutrition research”

This study suggests that estrogen regulates vitamin A metabolism in skin tissues in a sex-dependent manner, which may have implications for treating acne, hair loss, and skin immunity.

research Androgen receptor in rat liver: Characterization and separation from a male-specific estrogen-binding protein

24 citations , January 1989 in “Archives of biochemistry and biophysics”

This study found that androgen binding in male rat livers involves specific androgen receptors, which decrease with castration and are inducible in female livers with testosterone.

research Local synthesis and effect of sex steroids in human skin and the hair follicle and hormonal effects on the wound healing response

January 2011 in “Padua Research Archive (University of Padua)”

This study suggests that human skin locally synthesizes active sex steroid hormones, impacting inflammation, cell behavior, and wound healing, with potential implications for therapies in aging and impaired wound recovery.

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Learn

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learn Alfatradiol

a synthetic estrogen used topically as an anti-androgen

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn Overview

learn sh-Polypeptide-7

Is sh-Polypeptide-7 considered a natural or synthetic ingredient, and how is it typically applied? sh-Polypeptide-7 is a synthetic ingredient applied in hair-care products.

learn Glycerin

What’s the difference between vegetable glycerin and synthetic glycerin in hair products? Vegetable glycerin is plant-derived, while synthetic glycerin is petroleum-based, but both are chemically identical.

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Community Join

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community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

27 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

community Genetic variations associated with response to Dutasteride. Why is it never mentioned?

in Research/Science 26 upvotes 1 year ago

Genetic variations influence how people respond to dutasteride for hair loss, with some benefiting more from finasteride. Dutasteride is effective for most, but genetic differences may cause it to be less effective for some.

community Reversing Hairloss with 7α-Methyl-19-Nortestosteron aka Trestolone

7 upvotes 1 year ago

The user experienced significant hair regrowth using Trestolone, GHK-Cu, and Minoxidil. They avoided Finasteride due to concerns about side effects and noted that their approach reduced androgenic load, contributing to hair regrowth.

community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

55 upvotes 2 years ago

A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

community Trying to understand finasteride side effects and post finasteride syndrome

70 upvotes 5 years ago

The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

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