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Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

research Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

402 citations , August 2011 in “Cancer research”

This study found that castration-resistant prostate cancers resistant to CYP17A1 inhibitors may still depend on steroids and could respond to therapies targeting de novo intratumoral steroid synthesis.

research Green Synthesis of Silver Nanoparticles by UsingZiziphus nummulariaLeaves Aqueous Extract and Their Biological Activities

45 citations , January 2016 in “Journal of Nanomaterials”

In this study, silver nanoparticles derived from Ziziphus nummularia leaf extract showed enhanced antibacterial, antifungal, antioxidant, and hair growth properties compared to the leaf extract itself.

research Synthesis, antiproliferative, acute toxicity and assessment of antiandrogenic activities of some newly synthesized steroidal lactams

23 citations , February 2010 in “European Journal of Medicinal Chemistry”

research Green Synthesis of Silver Nanoparticles Using Medicinal Plant Tridax Procumbens Fresh Leaves and Biological Activities

April 2022 in “International journal of green and herbal chemistry”

This article discusses the green synthesis of silver nanomaterials using Tridax procumbens and reports no new clinical findings.

Green Synthesis of Silver Nanoparticles Using Grewia Optiva Leaf Aqueous Extract and Isolated Compounds as Reducing Agent and Their Biological Activities

research Green Synthesis of Silver Nanoparticles Using Grewia optiva Leaf Aqueous Extract and Isolated Compounds as Reducing Agent and Their Biological Activities

31 citations , October 2020 in “Journal of nanomaterials”

This study suggests that silver nanoparticles synthesized using Grewia optiva leaf extract exhibit stronger antibacterial and antioxidant properties than the leaf extract alone.

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community JW Pharmaceutical shows superiority of 'JW0061' in hair growth over existing treatments in US

in Research/Science 99 upvotes 2 years ago

JW0061 shows superior hair growth results compared to existing treatments, with significant increases in hair follicles. The Wnt/β-catenin pathway is crucial for hair growth, and JW0061 activates this pathway effectively.

community Thoughts about ORAL ketoconazole? (pills)

8 months ago

Oral ketoconazole is discussed as a potential hair loss treatment, but it poses significant health risks like liver damage and adrenal insufficiency. Users suggest safer alternatives like topical anti-androgens or spironolactone, emphasizing the importance of consulting a specialist.

community How finasteride lowers brain's happiness steroid allopregnanolone and causes depression: systemic dihydroprogesterone crosses blood brain barrier, you don't even need finasteride and brain 5ar for that

288 upvotes 1 year ago

Finasteride may lower allopregnanolone levels, potentially affecting mood, but many users report improved mental health due to reduced hair loss. Experiences with finasteride and dutasteride vary, with some experiencing side effects and others finding them beneficial for hair retention and overall happiness.

community Study: There is 70x Higher Unconjugated DHT in Feces Compared To Blood Levels in Young Adults - Gut Microbiota Manages DHT Recycling and Metabolism

in Research/Science 194 upvotes 1 year ago

Gut microbiota significantly influences androgen metabolism, impacting hair loss treatments like finasteride. Probiotics, dietary changes, and fecal microbiota transplants may help manage DHT levels and improve hair health.

community Interesting article links major MPB theories to western diet (and life-style)

in Research/Science 58 upvotes 1 year ago

Poor diet and lifestyle contribute to male pattern baldness. Treatments like Minoxidil, dietary changes, and lifestyle adjustments may help slow hair loss.

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