June 2016 in “Makedonski medicinski pregled” This case report describes severe hypotension, acute coronary syndrome, tachycardia, and acute kidney failure in a man who ingested topical minoxidil, with eventual recovery following intensive treatment.
248 citations
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November 2011 in “The EMBO Journal” This study found that Wnt1/βcatenin signaling plays a crucial role in activating the epicardium and cardiac fibroblasts, which supports cardiac repair following acute ischemic injury.
60 citations
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January 1989 in “Toxicologic Pathology” This paper discusses the pathogenesis of cardiovascular lesions in dogs associated with minoxidil, noting that lesions were not prevented by adrenergic blockade or neural activity suppression, and highlights the differences in injury progression between coronary arteries and the right atrium.
52 citations
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March 1979 in “Toxicology and Applied Pharmacology” Minoxidil can cause heart muscle damage in dogs.
40 citations
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July 1995 in “Toxicologic Pathology” In this study, glyburide prevented or significantly reduced cardiovascular lesions in dogs caused by minoxidil by blocking its hemodynamic effects, suggesting the toxicity is related to these profound effects rather than direct heart toxicity.