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research Phase I Safety and Pharmacokinetic Study of SU-014813 in Combination with Docetaxel in Patients with Advanced Solid Tumors

22 citations, May 2011 in “European Journal of Cancer”

In this Phase I study, 25 patients with advanced solid tumors were treated with SU-014813 and docetaxel to determine the maximal tolerated dose, evaluate pharmacokinetics, and assess anti-tumor efficacy. The recommended phase II dose was 75 mg/m² of docetaxel with 50 mg/day of SU-014813. Dose-limiting toxicities included neutropenia, neutropenic fever, fatigue, and diarrhea. Common side effects were fatigue, alopecia, nausea, vomiting, anorexia, rash, hypertension, and hair discoloration. The clinical benefit rate was 37.5%, with 2 patients achieving partial responses and 7 patients having stable disease for over 6 months. The combination showed manageable safety and promising anti-tumor activity, particularly in melanoma and sunitinib-refractory gastrointestinal stromal tumors, warranting further development.

research Unusual Progression of Renal Cell Carcinoma with Carcinomatosis Peritoneii and Krukenberg Tumor and Alopecia with Sunitinib Therapy in a Young Female

4 citations, February 2018 in “World journal of surgical oncology”

A young woman with kidney cancer experienced rare hair loss from a cancer drug and unusual cancer spread, suggesting early drug treatment might reduce spread and prolong survival.

research An Integrated Analysis of Cashmere Fineness lncRNAs in Cashmere Goats

26 citations, April 2019 in “Genes”

lncRNA XLOC_008679 and gene KRT35 affect cashmere fineness in goats.

research A Pilot Study of Intrascalp Platelet-Rich Plasma Injections for Hair Loss in Nigerian Patients

November 2020 in “Journal of The American Academy of Dermatology”

The conclusion is that many small genetic variations influence claw disorders in cows, and using genomic selection could help reduce these disorders.

Generating Detailed Intercellular Communication Patterns in Psoriasis at the Single-Cell Level Using Social Networking, Pattern Recognition, and Manifold Learning Methods to Optimize Treatment Strategies

research Generating Detailed Intercellular Communication Patterns in Psoriasis at the Single-Cell Level Using Social Networking, Pattern Recognition, and Manifold Learning Methods to Optimize Treatment Strategies

January 2024 in “Aging”

New insights into cell communication in psoriasis suggest innovative drug treatments.

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community Pérdida de cabello en jóvenes (15-20 años) mi experiencia.

in Treatment 20 upvotes 1 month ago

A 19-year-old shares his hair loss experience and treatment routine, which includes 1mg finasteride daily, 2mg oral minoxidil daily, ketoconazole shampoo every 2 days, and a healthy lifestyle. He notes that oral minoxidil is showing better results than topical minoxidil.

community 7 months on just topical finasteride (caretopic)

in Progress Pictures 52 upvotes 3 months ago

A user shared their 7-month progress using only topical finasteride for hair loss. They recently started a new, non-FDA treatment and will evaluate its effectiveness in 6 months.

community Does this mean it's finally working

in Finasteride/Dutasteride 2 upvotes 1 month ago

The user started using topical minoxidil in June 2023 and switched to a new finasteride preparation and vitamin D supplements a month ago. They noticed reduced hair shedding recently and are hopeful for regrowth.

community 2018 - 2024 (Fin -> Fin + Min)

in Progress Pictures 126 upvotes 4 months ago

The user shared progress on hair loss treatment, starting finasteride in 2018 and adding minoxidil in November 2023, with significant improvement. The user started treatment at age 31.

community ORAL MIN ,DERMAROLLING AND RU58841 PROGRESS 3 months (18,M)

in Progress Pictures 80 upvotes 1 year ago

The conversation is about an 18-year-old's progress with hair regrowth using oral Minoxidil, dermarolling, and RU58841 over three months, starting treatment after beginning to lose hair at 16. Participants are impressed with the improvement and encourage continued treatment.

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