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GlossarySunitinib (SU11248)

medication that inhibits enzymes to treat certain cancers

Sunitinib, also known by the brand name Sutent, is a medication used to treat certain types of cancer, including kidney cancer and gastrointestinal stromal tumors. It works by inhibiting multiple protein kinases, which are enzymes involved in the growth and spread of cancer cells.

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research Hair Depigmentation Is a Biological Readout for Pharmacological Inhibition of KIT in Mice and Humans

73 citations, September 2003 in “Journal of Pharmacology and Experimental Therapeutics”

Hair color loss can indicate the effectiveness of a drug targeting the KIT protein in mice and humans.

research Drug-Induced Skin, Nail, and Hair Disorders

114 citations, January 2007 in “Drug Safety”

Some drugs can cause skin, nail, and hair problems, which are important for healthcare professionals to recognize and report.

research Non-Rash Skin Toxicities Associated with Novel Targeted Therapies

28 citations, December 2006 in “Clinical lung cancer”

Early recognition and management of skin side effects from new cancer therapies can prevent treatment delays.

[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) Inhibits SCF/c-kit Signaling in 501mel Human Melanoma Cells and Abolishes Melanin Production in Mice and Brownish Guinea Pigs

research [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) Inhibits SCF/c-kit Signaling in 501mel Human Melanoma Cells and Abolishes Melanin Production in Mice and Brownish Guinea Pigs

26 citations, July 2007 in “Biochemical Pharmacology”

ISCK03 stops melanin production in human melanoma cells and lightens skin color in mice and guinea pigs.

research Hair Repigmentation Associated with the Use of Lenalidomide: Graying May Not Be an Irreversible Process

25 citations, March 2012 in “Journal of oncology pharmacy practice”

An 81-year-old man's white hair began to regain its original color while he was treated with lenalidomide, suggesting that graying hair might be reversible.

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