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      community 21M in Egypt Seeking Oral Minox Alternatives Due to Safety Concerns with Cat

      in Treatments  197 upvotes 1 week ago
      A user in Egypt is seeking alternatives to oral minoxidil, which is banned there, after stopping topical minoxidil due to concerns for their cat's safety. Suggestions include drinking diluted topical minoxidil or making homemade minoxidil tablets, but these methods carry significant risks and are not recommended.

      community DUPA, Non Responders and Connective Tissue Disorders

      in Research/Science  9 upvotes 6 months ago
      A 27-year-old male with diffuse hair loss, including the donor area, did not respond to finasteride, dutasteride, or minoxidil. He suspects his hair loss may be linked to a mild connective tissue disorder, possibly affecting the structural support of hair follicles, rather than being purely hormonal.

      community PP405 (Non) Update - Feb 2025

      in Research/Science  34 upvotes 9 months ago
      The conversation discusses the delay in the PP405 Phase 2 study results, now expected by the end of 2025, and skepticism about research practices. There is also mention of optimism for Amplifica's AMP303 and a topical treatment in early testing.

      community My Delusional Hope - This page becomes irrelevant in 2030s

      in Chat  49 upvotes 1 month ago
      People are hopeful for a permanent hair loss solution by the 2030s, considering options like hair cloning and treatments like pp405. Synthetic hair transplants have been attempted but are not effective long-term.
      PP405 Identity Research

      community PP405 Identity Research

      in Research  292 upvotes 4 months ago
      PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.