research Acquired pili torti--a structural hair shaft defect in anorexia nervosa.
This study found that 82.3% of girls with anorexia nervosa had pili torti, an acquired hair defect, suggesting a potential link to excess vitamin A intake.
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5 / 1000+ resultsresearch Proteomic analysis of hair shaft and nail plate.
This study describes how shotgun proteomics can identify over 300 proteins in hair shafts, potentially allowing for the diagnosis of diseases through noninvasive human proteome sampling.
research Acquired Structural Defects of the Hair
This case study reports that selenium shampoo, bacterial infection with trichomycosis axillaris, and possibly strongyloides larvae may have contributed to acquired hair shaft abnormalities resembling trichorrhexis nodosa in two patients.
research Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75
This study demonstrated that RNA interference targeting mutant keratin genes can effectively correct hair shaft structural defects in a mouse model by reducing mutant gene expression.
research Trichoscopic Diagnosis of Structural Hair Defects in a Clinical Setting: A Cross-Sectional Analytical Study
This study found that most hair shaft abnormalities can be accurately diagnosed using a handheld dermoscope in a clinical setting.
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5 / 322 resultscommunity Why Fin/Dut Isn't Working for You GPR133: a new hairloss mechanism + Steroid Hair Loss Deep Dive
Hair loss may be linked to the GPR133 receptor, independent of the androgen receptor pathway. Treatments like finasteride, dutasteride, minoxidil, RU58841, and KX-826 show varying results, with hair loss persisting due to high testosterone and GPR133's role.
community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect
PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.
community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied
Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.
community FDA Policy Shift Explained: What It Actually Means for PP405, VDPHL-01, Breezula and Hair Loss Drug Timelines
The FDA policy change may speed up approval for hair loss drugs like PP405, VDPHL-01, and Breezula by potentially eliminating the need for a second confirmatory Phase 3 trial. Approval timelines could be as early as 2028 for some treatments if Phase 3 results are strong.
community New study suggests hair regrowth on wounded and bald skin may be possible
Hair regrowth on wounded and bald skin may be possible by activating the sonic hedgehog gene, leading to hair regrowth in mice. The findings are promising but may not directly apply to humans.
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3 / 800 resultslearn Osteopontin
signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
