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research Children and Adolescents with Alopecia Areata: Psychiatric Symptomatology and Life Events: A longitudinal case-control study: Before and During the COVID-19

May 2026 in “Research Square”

Children with alopecia areata often face more stress and depression, especially related to separation, which can affect their condition.

research Stress Inhibits Hair Growth in Mice by Induction of Premature Catagen Development and Deleterious Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways

194 citations , March 2003 in “American Journal of Pathology”

This study found that psychoemotional stress disrupts hair growth in mice by terminating anagen and suggests a potential pathway for pharmacological management of stress-related hair loss in humans.

research Life Events Preceding Alopecia Areata Onset—a Descriptive Retrospective Cohort Study Focusing on Strain

January 2026 in “Clinical Cosmetic and Investigational Dermatology”

This study found that among patients with alopecia areata, 82% reported experiencing at least one significant life event perceived as strainful in the two years before disease onset, suggesting an association between perceived stress and the onset of this condition.

research Nitroxide pharmaceutical development for age-related degeneration and disease

24 citations , November 2015 in “Frontiers in Genetics”

This review discusses the development and potential therapeutic effects of nitroxide small molecule agents for age-related macular degeneration and cardiovascular disease, but reports no new clinical results.

research Frontiers in the (Neuro-)endocrine Controls of Hair Growth

22 citations , November 2007 in “Journal of Investigative Dermatology Symposium Proceedings”

This presentation reviews recent discoveries about signaling mechanisms in hair follicles and their potential influence on hair cycle control and melanogenesis, without presenting new experimental results.

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community A stress hormone has been found to signal through skin cells to repress the activation of hair-follicle stem cells in mice

30 upvotes 5 years ago

Stress can lead to hair loss by affecting hair-follicle stem cells, and this loss is harder to recover from if one has male pattern baldness (MPB). Treatments like finasteride and minoxidil are used to address hair loss, but stress-related hair loss differs from androgenic alopecia.

community The ending of alopecia? Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence

63 upvotes 4 years ago

Corticosterone inhibits GAS6, affecting hair follicle stem-cell activity, with potential implications for stress-related hair loss. Ashwagandha and Vitamin K are suggested for reducing cortisol, but their effectiveness is debated.

community How the hell am I still losing hair

in Finasteride/Dutasteride 8 upvotes 1 year ago

The user has been experiencing sudden and aggressive hair shedding despite using oral dutasteride and topical minoxidil for six years, and recently added topical finasteride without improvement. Possible causes discussed include stress-related hair loss, dietary changes, or high DHT sensitivity, with suggestions to consult a doctor and consider adjusting treatments.

community Telogen Effluvium/Chronic TE and immune-related hair loss advice

5 upvotes 8 years ago

Chronic Telogen Effluvium can be managed by avoiding inflammatory foods, exercising, staying hydrated, and using supplements like krill oil, saw palmetto, or licorice root. Minoxidil is discouraged due to its cost and potential for worsening hair loss, while castor oil is recommended to strengthen hair roots and reduce shedding.

community Is RU558841 actually related to heart issues?

in Finasteride/Dutasteride 11 upvotes 1 year ago

RU58841 may cause heart-related side effects like palpitations and chest pain, though evidence is mostly anecdotal. Users report mixed experiences, with some stopping due to side effects and others using it without issues, but concerns about its safety and sourcing remain.

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Learn

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learn Overview

learn Epidermal Growth Factor

learn Vitamin B5

Is Vitamin B5 beneficial for people experiencing stress-related or nutritional hair loss? Vitamin B5 is not proven to help with stress-related or nutritional hair loss.

learn Vitamin B6

Is Vitamin B6 helpful for stress-related or hormonal hair loss? Vitamin B6 may support overall health but lacks strong evidence for preventing hair loss.

learn Lavender

Is lavender effective for hormonal hair loss or just stress? Lavender may help with stress-related hair loss but has limited evidence for hormonal hair loss.

learn Hair Transplant

How can I stop hair loss related to hair transplants? Adopt a nutritious diet, manage stress, and consult a specialist for tailored treatments.

learn PP405

Got small bald patches they say are from stress? PP405 sprays could help bring them back to life. PP405 is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier; its registered Phase 2 trial (NCT06393452) tested it once daily in 78 adults with pattern hair loss, for safety and tolerability. It is not approved, not for sale, and has not been studied in alopecia areata or stress-related shedding.

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Clinics

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TrichologyHair Loss Treatments
Glam 4 EventsRoseville, CA · US

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