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research Neuroactive Steroid Levels are Modified in Cerebrospinal Fluid and Plasma of Post‐Finasteride Patients Showing Persistent Sexual Side Effects and Anxious/Depressive Symptomatology

73 citations , July 2013 in “The Journal of Sexual Medicine”

This study observed that androgenic alopecia patients taking finasteride had altered neuroactive steroid levels and persistent depression symptoms even after stopping the treatment.

research Studies on the persistence of estradiol benzoate and nortestosterone decanoate in hair of cattle following treatment with growth promoters, determined by ultra-high-performance liquid chromatography–tandem mass spectrometry

18 citations , April 2009 in “Journal of Chromatography A”

Detecting steroid esters in cattle hair is inconsistent and influenced by sampling factors.

research Research Brief: Self-Reports of a Constellation of Persistent Antiandrogenic, Estrogenic, Physical, and Psychological Effects of Finasteride Usage Among Men

9 citations , January 2018 in “American Journal of Men's Health”

This study analyzed self-reports from discussion forums to categorize and understand adverse effects experienced by individuals using finasteride, suggesting a need for further investigation into post-finasteride syndrome.

research Patients treated for male pattern hair with finasteride show, after discontinuation of the drug, altered levels of neuroactive steroids in cerebrospinal fluid and plasma

61 citations , April 2014 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study reports that men with androgenic alopecia experience altered neuroactive steroid levels associated with persistent depression symptoms even after stopping finasteride treatment.

research Ovarian sex steroid receptors and sex hormones in androgenized rats

13 citations , August 2016 in “Reproduction”

In this study, nandrolone decanoate treatment in rats caused persistent diestrus and altered steroid receptor expression and sex hormones, especially at higher doses, with partial reversibility at lower doses over time.

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Community Join

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community Finasteride does deplete important nuero-active steroids

11 upvotes 3 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

community Dutasteride vs Finasteride and Steroid

in Progress Pictures 87 upvotes 11 months ago

Dutasteride is preferred over finasteride for hair loss due to fewer side effects. Combining dutasteride with minoxidil and RU58841 is effective for hair regrowth, even during steroid use.

community Why Fin/Dut Isn't Working for You GPR133: a new hairloss mechanism + Steroid Hair Loss Deep Dive

6 upvotes 2 months ago

Hair loss may be linked to the GPR133 receptor, independent of the androgen receptor pathway. Treatments like finasteride, dutasteride, minoxidil, RU58841, and KX-826 show varying results, with hair loss persisting due to high testosterone and GPR133's role.

community 22M Losing hair since 16, nothing helps, scalp always itchy. Just fed up.

in Treatment 59 upvotes 11 months ago

A 22-year-old experiencing hair loss and persistent scalp itchiness since age 16 has tried various treatments, including finasteride, ketoconazole shampoo, and dietary changes, with no success. Suggestions include consulting a knowledgeable dermatologist, considering seborrheic dermatitis, and trying different shampoos like Selsun Blue or those with selenium sulfide.

community PSA: Most men who stay on Fin will see the sexual side effects go away. Stop the fear mongering

192 upvotes 4 years ago

Finasteride can cause sexual side effects in less than 2% of men, but these often disappear over time, even if the treatment continues. Some users report persistent side effects, while others experience no issues or only temporary ones.

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Learn

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learn Hydrocortisone

Can hydrocortisone be used together with other treatments like minoxidil or steroid injections? If minoxidil solution irritates the scalp, the cause may be irritation, seborrhoeic dermatitis or an allergy to an ingredient, so it is worth having a doctor or pharmacist look before adding a steroid. No verified trial tests hydrocortisone alongside minoxidil or corticosteroid injections, and prolonged scalp use risks skin thinning.

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