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In this study, researchers used genomic, metabolomic, and transcriptomic methods to explore the biosynthetic capabilities of S. longa, aiming to better understand the species and lay the groundwork for future studies on the biosynthesis and therapeutic use of cepharanthine and similar alkaloids.

In this study, researchers identified specific Se6OMT enzymes in *S. epigaea* involved in the cepharanthine biosynthetic pathway, providing insights into their substrate promiscuity and essential genetic components for metabolic engineering and synthetic biology applications of cepharanthine production.

This study found that bisbenzylisoquinoline alkaloids from Stephania cepharantha Hayata stimulated growth in cultured murine hair cells but not in keratinocytes or fibroblasts.

This study identified seven reliable putative microRNAs in Stephania japonica, which may regulate cepharanthine biosynthesis by targeting specific transcription factors.

This review examines cepharanthine's antiviral potential against COVID-19 and finds no clinical results yet; it highlights cepharanthine as a potent inhibitor of coronavirus in preclinical models.