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Did you mean JAK-STAT signaling pathway?

GlossaryJAK-STAT pathway

transmits signals from cell surface to nucleus for gene expression

The JAK-STAT pathway, short for Janus kinase-signal transducer and activator of transcription pathway, is a chain of interactions between proteins in a cell that transmits signals from chemical signals outside the cell to the cell nucleus, resulting in DNA transcription and activity changes. This pathway is crucial for regulating immune function, cell growth, and development, and has been implicated in various diseases, including certain types of alopecia and cancers.

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Heavy duty finasteride that comes with higher risks, but scalp injections seem safe and are gaining popularity

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research Effects of Periplaneta Americana Extracts on the Growth and Proliferation of Cutaneous Interstitial Cells in Cutaneous-Wound Healing

9 citations, August 2022 in “Frontiers in Pharmacology”

Kangfuxin (KFX) extract speeds up wound healing and improves skin regeneration.

research Two Distinct Signaling Pathways in Hair Cycle Induction: Stat3-Dependent and Independent Pathways

73 citations, November 2000 in “Proceedings of the National Academy of Sciences of the United States of America”

There are two ways to start hair growth: one needs Stat3 and the other does not, but both need PI3K activation.

research Saw Palmetto Extract Inhibits Metastasis and Antiangiogenesis Through STAT3 Signal Pathway in Glioma Cells

6 citations, January 2015 in “Evidence-based Complementary and Alternative Medicine”

Saw palmetto extract may help treat brain tumors by blocking a specific growth signal and blood vessel formation.

research Wound Regeneration Deficit in Rats Correlates with Low Morphogenetic Potential and Distinct Transcriptome Profile of Epidermis

21 citations, January 2018 in “Journal of Investigative Dermatology”

Rats can't grow new hair follicles after skin wounds, unlike mice, due to differences in gene expression and response to WNT signaling.

research Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth

159 citations, October 2015 in “Science Advances”

Blocking JAK-STAT signaling can lead to hair growth.

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community What else is good. Besides the big 3.

Ill-Passenger-2468 in Chat 34 upvotes 4 months ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

HMI115_GIGACHAD in Research/Science 126 upvotes 1 year ago

The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

community NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

Robbsaber in Research/Science 14 upvotes 8 months ago

NMN shows promise in promoting hair growth by reducing oxidative stress and weakening androgens. It may be a beneficial addition to hair loss treatments like Minoxidil and Finasteride.

community I started rapidly diffuse thinning at 22. I'm 42 now and have as much hair as I did at 16. AMA

karlallan in Treatment 443 upvotes 4 years ago

Hair loss treatments like finasteride, minoxidil, ketoconazole, PRP, and microneedling helped maintain hair for 20 years. Research and try evidence-based treatments for best results.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

asyntheticpug in Research/Science 732 upvotes 2 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

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