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GlossaryStratum Spinosum (spinous layer)

layer of the epidermis with spiny-shaped keratinocytes

The Stratum Spinosum, also known as the spinous layer or prickle cell layer, is a layer of the epidermis located just above the Stratum Basale. It consists of several layers of keratinocytes that are connected by desmosomes, which give the cells a spiny appearance under a microscope. This layer plays a crucial role in providing strength and flexibility to the skin.

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research Hair Follicle Morphogenesis and Epidermal Homeostasis in We/We Wal/Wal Mice with Postnatal Alopecia

7 citations, November 2014 in “Histochemistry and Cell Biology”

The we/we wal/wal mice have defects in hair growth and skin layer formation, causing hair loss, useful for understanding alopecia.

research Hair Cycle-Specific Immunolocalization of Retinoic Acid Synthesizing Enzymes Aldh1a2 and Aldh1a3 Indicate Complex Regulation

29 citations, July 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

The enzymes Aldh1a2 and Aldh1a3 are involved in making retinoic acid in hair follicles and have different roles in hair growth.

research Follicular Porokeratosis: Four New Cases

6 citations, July 2017 in “Clinical and Experimental Dermatology”

Four new cases confirmed the unique features of follicular porokeratosis.

research Reflectance Confocal Microscopy of Adult Periorificial Dermatitis: A Case Report

July 2023 in “Clinical, cosmetic and investigational dermatology”

Reflectance confocal microscopy helped tell periorificial dermatitis apart from similar skin conditions.

research Reflection Confocal Microscope Characteristics of Rosacea and Related Observations

July 2022 in “Skin research and technology”

Skin CT can help diagnose rosacea by identifying specific skin features, but should be used with clinical signs to avoid misdiagnosis.

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community The story of RU58841/ PSK3841

in Research 622 upvotes 3 months ago

RU58841, a potential hair loss treatment, was not commercialized due to marketability issues and lack of long-term safety data. Concerns about its formulation and delivery methods further complicate its use.