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GlossaryStratum Spinosum (spinous layer)

layer of the epidermis with spiny-shaped keratinocytes

The Stratum Spinosum, also known as the spinous layer or prickle cell layer, is a layer of the epidermis located just above the Stratum Basale. It consists of several layers of keratinocytes that are connected by desmosomes, which give the cells a spiny appearance under a microscope. This layer plays a crucial role in providing strength and flexibility to the skin.

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research Bikunin, a Serine Protease Inhibitor, Is Present on the Cell Boundary of Epidermis

13 citations , August 1999 in “Journal of Investigative Dermatology”

Bikunin is found on the cell boundaries of certain skin layers and may help regulate skin and hair functions.

research Desmosomes in Developing Human Epidermis

11 citations , January 2010 in “Dermatology Research and Practice”

Desmosomes are crucial for human skin development, increasing in density as the skin matures.

research Specific Receptor Detection by a Functional Keratinocyte Growth Factor-Immunoglobulin Chimera

66 citations , April 1995 in “The journal of cell biology/The Journal of cell biology”

A new protein was made to detect specific skin cell growth receptors and worked in normal skin but not in skin cancer cells.

research Keratin and Skin Disorders

28 citations , April 1996 in “Cell biology international”

Changes in keratin affect skin health and can lead to skin disorders like blistering diseases and psoriasis.

research Mechanisms Regulating Skin Immunity and Inflammation

610 citations , April 2014 in “Nature Reviews Immunology”

The document concludes that understanding how the skin's immune system and inflammation work is complex and requires more research to improve treatments for skin diseases.

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community The story of RU58841/ PSK3841

Typical-Promise-3001 in Research 622 upvotes 1 year ago

RU58841, a potential hair loss treatment, was not commercialized due to marketability issues and lack of long-term safety data. Concerns about its formulation and delivery methods further complicate its use.