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A Spermidine-Based Nutritional Supplement Prolongs the Anagen Phase of Hair Follicles in Humans: A Randomized, Placebo-Controlled, Double-Blind Study

research A Spermidine-Based Nutritional Supplement Prolongs the Anagen Phase of Hair Follicles in Humans: A Randomized, Placebo-Controlled, Double-Blind Study

8 citations, October 2017 in “Dermatology practical & conceptual”

A spermidine-based supplement may help hair grow longer by keeping it in the growth phase.

research Novel Aspects of Age-Protection by Spermidine Supplementation Are Associated with Preserved Telomere Length

20 citations, January 2021 in “GeroScience”

Spermidine helps protect against aging by preserving telomere length.

research The Pioneer Factor SOX9 Competes for Epigenetic Factors to Switch Stem Cell Fates

6 citations, July 2023 in “Nature cell biology”

SOX9 helps determine stem cell roles by interacting with DNA and proteins that control gene activity.

research Piezo1-Mediated Calcium Signaling Reinforces Mechanical Properties Of Hair Follicle Stem Cells To Promote Quiescence

May 2025 in “Science Advances”

PIEZO1 helps keep hair follicle stem cells inactive, affecting hair growth.

research Comparative Studies on Polyamine Levels in Plasma and Urine of Androgenic Alopecia Patients Treated with Finasteride for a Period of Three Years

January 2020 in “International Journal of Applied Biology and P”

Finasteride treatment for three years changes certain polyamine levels in the blood but not in urine.

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Community Join

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community How to reduce cortisol (stress hormone) naturally?

in Chat 37 upvotes 3 years ago

The conversation discusses natural ways to reduce cortisol, such as avoiding caffeine, getting proper sleep, syncing with the sun, walking in nature, breathing exercises, increasing calories, and not doing keto. Magnesium supplements are recommended for stress reduction.

community What else is good. Besides the big 3.

in Chat 35 upvotes 8 months ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

community 5 month results on natural protocol, i made a post after 3 mont of treatment wich you can find in my profile. I used different massages(detumescence therapy, wooden brush, tom hagerty exercises)vitamins(d3,fish oil, biotin,msm, magnesium) drank green tea and ate pumpkin seeds( reduces dht)

in Is this regrowth? 150 upvotes 1 year ago

The user "Zealousideal-Pack340" shared their 5-month results on a natural hair loss treatment protocol, which included massages, vitamins, green tea, and pumpkin seeds. Some users suggested using medications like finasteride and minoxidil for better results, while others criticized the effectiveness of natural remedies. Overall, there was no clear consensus on the progress of the user's hair regrowth.

community Research suggests that drugs rapamycin and metformin have hair regeneration properties

2 upvotes 7 years ago

Rapamycin and metformin may have hair regeneration properties. Specific treatments discussed include Minoxidil, finasteride, and RU58841.

community Nice product I discovered, thought I would share.

in Treatment 456 upvotes 1 month ago

A product that makes hair look thicker and healthier without promoting regrowth. Discussions include treatments like minoxidil, finasteride, red light therapy, and a serum with caffeine and peptides, with mixed effectiveness opinions.