104 citations
,
October 1999 in “The Journal of Urology” This study concluded that daily treatment with 1 mg finasteride did not affect spermatogenesis or semen production in young men and had small, reversible effects on prostate volume and serum PSA.
49 citations
,
December 2007 in “Fertility and Sterility” This case report describes two infertile patients who experienced significant improvements in sperm concentrations six months after stopping finasteride.
18 citations
,
June 2009 in “Journal of Molecular Endocrinology” This study found that exposure to finasteride impaired spermatogenesis in male Xenopus laevis by affecting sex-specific feedback mechanisms in the hypothalamus–pituitary–gonad axis.
18 citations
,
May 2002 in “BJUI” This study found that chronic exposure to finasteride did not significantly impact spermatogenesis in rats.
15 citations
,
March 2015 in “PloS one” This study demonstrated that an AR-EGFP transgene can restore AR function and fertility in Sertoli cell-specific AR knockout mice, highlighting its potential use in understanding androgen receptor functions.