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This review discusses the role of the sonic hedgehog pathway in skin development and cancer, highlighting its potential as a target for chemoprevention and treatment; it reports no new findings.

This study found that downregulation of Sonic hedgehog signaling may promote HPV replication and wart formation by inducing cell cycle arrest in keratinocytes.

This study demonstrates that mice with ectopic expression of the human GLI-1 gene in their skin developed tumors resembling human basal cell carcinoma, suggesting that GLI-1 is central to tumor development without additional p53 or Ha ras mutations.

In this study, repressing β-catenin/Lef1 signalling in mouse epidermis led to progressive hair loss, dermal cysts, and spontaneous skin tumors with sebaceous differentiation, indicating altered keratinocyte differentiation and potential tumourigenic processes.

This study found that in early retinal neurogenesis in mice, the transcription factor Lhx2 regulates Sonic Hedgehog signaling by controlling expression of pathway genes like the co-receptors Gas1 and Cdon.