39 citations
,
December 2001 in “JNCI: Journal of the National Cancer Institute” This study found that enhanced expression of the Sonic hedgehog gene via an adenovirus vector accelerated hair regrowth in mice with chemotherapy-induced alopecia.
17 citations
,
January 2007 in “Annals of Medicine” This review discusses advancements and challenges in cutaneous gene therapy using direct and indirect techniques, noting that while clinical translation has begun, further developments are essential for progress.
14 citations
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January 2008 in “Gene therapy” Gene therapy shows promise for enhancing physical traits but faces ethical, safety, and regulatory challenges.
231 citations
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October 1999 in “Journal of Clinical Investigation” This study found that administering an adenovirus vector to increase Sonic hedgehog gene expression in mouse skin accelerated the transition of hair follicles into the growth phase, promoting hair growth.
June 2025 in “Stem Cell Research & Therapy” This review highlights recent advancements in androgenetic alopecia treatment, focusing on the dysregulated signaling pathways involved in hair follicle regeneration and exploring innovative therapeutic strategies, including small molecule modulators and gene editing technologies, which show promise in preclinical models.