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learn SODIUM ACRYLATES COPOLYMER

learn Dutasteride

Dutasteride: Why don't some doctors prescribe it if it's stronger than finasteride? Some doctors avoid prescribing dutasteride due to its higher risk of side effects.

learn Finasteride

Do you want finasteride to penetrate better? The ideal solvent to maximize its effect. Formulation sources describe propylene glycol and microemulsion vehicles as increasing how much topical finasteride crosses the skin, but better penetration has not been shown to mean better hair results, and it also raises systemic exposure. The vehicle and strength are decisions for a prescriber or compounding pharmacist.

learn Scalp Micropigmentation

How soon can I exercise after scalp micropigmentation? Avoid heavy exercise for 4-10 days after scalp micropigmentation to ensure proper healing.
How soon can I resume normal activities after scalp micropigmentation? Providers commonly say normal daily activity can resume within a day of scalp micropigmentation, with about half restricting exercise for 5 to 10 days and about half saying full activity waits 2 to 3 weeks. Follow the aftercare your own practitioner gives you.
How soon can I get started with scalp micropigmentation? You can often start scalp micropigmentation within a week to a few weeks.

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Community Join

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community So is dutasteride worse than fin? What are all these posts? If anyone had positive experience with switching from fin to dut please dont skip.

6 upvotes 4 weeks ago

The conversation is about switching from finasteride to dutasteride for hair loss treatment. Users discuss shedding experiences and suggest taking both medications daily for several months before dropping finasteride.

community So why did the first pyrilutamide phase III fail?

4 upvotes 1 month ago

Pyrilutamide's inconsistent trial results, with phase II showing positive hair growth and phase III failing to show significant gains, possibly due to COVID-related disruptions. Users discuss modest results from kx-826 treatment.

community So the cure for Nw7 is verteporfin

7 upvotes 1 month ago

Verteporfin, used with dermal incisions by doctors like Dr. Melissa Toyos, is suggested as a promising treatment for high Norwood hair loss, with some users reporting significant regrowth. However, there is skepticism about its effectiveness due to concurrent use of other treatments like dutasteride and oral minoxidil.

community So what happened here with Landon Donovan?!

863 upvotes 3 months ago

Landon Donovan is using a hair system, not a hair transplant, as previous transplants were unsuccessful. The hair system significantly improved his appearance, making him look younger.

community So is this the actual trial results for pp405?????

94 upvotes 5 months ago

PP405 shows promising results for hair growth, potentially outperforming finasteride without side effects like erectile dysfunction. Users discuss using treatments like minoxidil, pyrilutamide, nizoral, and alfatradiol while waiting for PP405's availability.

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Research

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research Solid Lipid Nanoparticles for Drug Delivery: Pharmacological and Biopharmaceutical Aspects

559 citations , October 2020 in “Frontiers in Molecular Biosciences”

This review reports on the current state and potential of solid lipid nanoparticles for drug delivery, emphasizing their safety, biocompatibility, and ease of production, and highlights challenges in translating them to clinical practice, including active clinical trials.

research Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells

396 citations , May 2011 in “Cell stem cell”

This study found that Shh from neurons signals to Gli1-expressing cells in the hair follicle, cultivating a niche where these bulge cells can potentially transform into epidermal stem cells in wound healing.

Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins

research Acidic and basic hair/nail ("hard") keratins: their colocalization in upper cortical and cuticle cells of the human hair follicle and their relationship to "soft" keratins.

356 citations , December 1986 in “The journal of cell biology/The Journal of cell biology”

This study found that specific human hair keratins are differentially expressed in the hair follicle, suggesting a shared pathway of epithelial differentiation between hair cortex and nail plate cells.

research Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis

338 citations , July 2009 in “Development”

This study demonstrates that Sox2-positive dermal papilla cells specify particular hair follicle types by showing heterogeneity in gene expression and pathway activation in these cells.

research Podophyllotoxin-loaded solid lipid nanoparticles for epidermal targeting

297 citations , December 2005 in “Journal of controlled release”

This study found that POD-loaded solid lipid nanoparticles using 0.5% poloxamer 188 and 1.5% soybean lecithin (P-SLN) improved epidermal targeting and POD accumulation in porcine skin compared to traditional tincture.

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