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      research Small Molecule Agents Against Alopecia: Potential Targets and Related Pathways

      July 2024 in “European Journal of Medicinal Chemistry”
      This review discusses the increasing prevalence of alopecia in younger populations and outlines the need for better understanding its pathogenesis to develop effective treatments. It also examines current FDA-approved drugs and emerging small molecule compounds with potential anti-alopecia effects.
      Targeting Integrin Pathways: Mechanisms and Advances in Therapy

      research Targeting integrin pathways: mechanisms and advances in therapy

      54 citations , January 2023 in “Signal Transduction and Targeted Therapy”
      This review examines integrins as pharmacological targets, discussing current integrin-based therapies and emphasizing the need to understand integrin mechanisms for successful drug development, without reporting new clinical results.
      Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear

      research Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear

      26 citations , October 2023 in “Neuroscience Bulletin”
      In this review, the authors discuss how understanding and co-regulating multiple signaling pathways could lead to effective regeneration of functional hair cells, highlighting current achievements and future approaches such as small molecule drugs and gene therapy for treating sensorineural hearing loss.

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      learn PP405

      mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials

      learn Exosomes

      Microscopic delivery system that sends growth-promoting signals to hair follicles

      learn Osteopontin

      signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss