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research Fermented grapeseed oil repairs chemically damaged hair via enhanced permeability mechanisms

July 2025 in “Scientific Reports”

This study reported that fermented grapeseed oil may enhance hair permeability and improve strength and color retention in chemically treated hair compared to regular grapeseed or silicone oils.

research Editorial: Crosstalk: skin cells and immune cells in inflammatory skin diseases

3 citations , August 2024 in “Frontiers in Immunology”

This source reports that understanding how skin cells and immune cells interact may lead to better treatment options for inflammatory skin diseases like psoriasis and atopic dermatitis, emphasizing the role of epithelial-immune microenvironments in disease pathogenesis.

Novel Small Molecules Downregulate CDK1 Expression and Inhibit Wnt/β-Catenin Signaling in Cutaneous Squamous Cell Carcinoma by Targeting Its Distinct Tumor-Specific Cellular Landscape

research Novel small molecules downregulate CDK1 expression and inhibit Wnt/β-catenin signaling in cutaneous squamous cell carcinoma by targeting its distinct tumor-specific cellular landscape

September 2025 in “Experimental & Molecular Medicine”

This study observed that the small molecules KY19382 and KY19334 inhibited cancerous traits in human cutaneous squamous cell carcinoma cells by suppressing the Wnt/β-catenin pathway, indicating their potential as treatments for cancers involving CDK1 overexpression and diseases related to CXXC5 accumulation.

research Modulation of Hair Growth with Small Molecule Agonists of the Hedgehog Signaling Pathway

113 citations , September 2005 in “Journal of Investigative Dermatology”

This study found that a topical hedgehog agonist can stimulate hair growth by promoting the transition from the resting to growth phase of the hair cycle in adult mouse skin.

research Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened

63 citations , May 2011 in “Clinical cancer research”

In this study, topical CUR61414 was effective in inhibiting basal cell carcinomas in mice, but no clinical activity was observed in human trials.

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community Topical finasteride making. Powder not disolving

4 upvotes 3 years ago

OP is trying to dissolve finasteride powder for a topical solution but faces issues with it not dissolving properly in ethanol or water. Users suggest methods like using a magnetic stirrer, shaking the mixture, or filtering out fillers, with some noting that finasteride is soluble in alcohol.

community Have any of you given Nanoxidil a try?

4 upvotes 4 years ago

Nanoxidil is discussed as a potential alternative to Minoxidil for hair loss, with some users reporting better results and improved hair strength. However, concerns about its lack of FDA approval and potential scalp dryness are noted.

community 1 month after switching to topical Dut

in Is this regrowth? 216 upvotes 2 months ago

The user switched from topical finasteride/minoxidil to topical dutasteride/minoxidil, reporting thicker hair after one month. They used Happy Head products with 0.3% dutasteride and 8% minoxidil.

community Has anyone heard of Trioxidil instead of Minoxidil?

8 years ago

Trioxidil's effectiveness is questioned, with users suggesting it might be a marketing gimmick. Alternatives like Lipogaine and MSM are discussed, with some users sharing positive experiences with combining treatments like minoxidil and nanoxidil.

community Creating Custom Topicals: A Guide (2025 Edition)

27 upvotes 10 months ago

Creating custom topical treatments for hair loss using minoxidil, finasteride, and RU58841. It includes recipes and instructions for home preparation, focusing on cost savings and customization.

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