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research Canonical prolactin signaling and global mRNA expression in the skin of Holstein heifers carrying the SLICK1 allele of the prolactin receptor gene

1 citations , February 2025 in “Journal of Dairy Science”

In this study, researchers found that the SLICK1 allele in cattle may alter local immune regulation, hair growth, and tissue remodeling, as indicated by differential gene expression pathways associated with immune and inflammatory responses in slick vs. nonslick Holsteins.

research The slick hair coat locus maps to chromosome 20 in Senepol-derived cattle

51 citations , January 2007 in “Animal Genetics”

This study identified the location of the genetic locus for the slick hair coat trait in cattle on bovine chromosome 20, which may contribute to heat tolerance.

research Effects of the bovine slick mutation on heat stress responses and hair growth in mice

January 2020

This study found that bovine slick mutations may enhance heat stress responses in mice but do not lead to the expected hair phenotype changes.

research Genetic architecture of thermotolerance traits in beef cattle: a novel integration of SNP and breed-of-origin effects

April 2025 in “Frontiers in Genetics”

This study found that integrating breed-specific BOA and SNP-based models helps reveal the genetic factors involved in thermotolerance traits in beef cattle, enhancing insights into thermoregulation and potentially improving cattle's heat resilience.

research Use of genetics in the prediction of success in male pattern hair loss therapy and mechanistic studies

February 2026 in “Frontiers in Pharmacology”

This review suggests a shift toward genetically informed treatments for male pattern hair loss by integrating genetic insights and pharmacogenetic markers into therapeutic decision-making.

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community 1% keto shampoo, 5% minox foam, and the ordinary multi peptide hair serum. Is this better than nothing?

in Ketoconazole 3 upvotes 5 months ago

The user is using 1% ketoconazole shampoo, 5% minoxidil foam, and a multi-peptide hair serum to address hair loss, aiming to improve from Norwood 5 to Norwood 3. They are considering adding topical finasteride if current treatments show progress and plan to use cosmetic products like fibers and DermMatch for appearance enhancement.

community Quote from Pelage (PP-405) Spokesperson...

122 upvotes 10 months ago

Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.

community PP405 Phase 2a press release with early results

700 upvotes 1 year ago

PP405 shows promise in hair regrowth, with 31% of participants experiencing over 20% increase in hair density after 8 weeks. Phase 3 trials are expected in 2026, with potential market availability by 2029-2031.

community “I’ll be happy as soon as fin brings my hair back” march 21, 2023

138 upvotes 1 year ago

The user is struggling with hair loss and has tried treatments like finasteride, minoxidil, and dutasteride without success, considering a hair transplant as a future option. Others suggest focusing on mental health and self-worth beyond physical appearance, while some share their own experiences with similar treatments and outcomes.

community I understand this topic has been discussed countless times, but hair loss is the most brutal experience for men.

in Chat 343 upvotes 1 year ago

Hair loss significantly affects men's confidence and mental health. Common treatments include finasteride, dutasteride, and minoxidil, with some considering hair transplants.

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