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GPX4 mRNA Levels in Polymorphonuclear Neutrophils Are Negatively Correlated with Autoantibody Production, Disease Activity, and Lupus Alopecia in Systemic Lupus Erythematosus

research GPX4 mRNA levels in the PMNs are negatively correlated with autoantibody production, disease activity and lupus alopecia in SLE

April 2023 in “Research Square (Research Square)”

This study found that lower GPX4 mRNA levels in polymorphonuclear neutrophils of systemic lupus erythematosus patients were negatively associated with disease activity and serological markers, suggesting a diagnostic value for GPX4 mRNA.

Clinical and Trichoscopic Patterns of Hair Loss in Systemic Lupus Erythematosus and Its Correlation with Systemic Lupus Erythematosus Disease Activity Index

research Clinical and Trichoscopic Patterns of Hair Loss in Systemic Lupus Erythematosus and its Correlation with Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)

May 2018

In this study, chronic telogen effluvium was identified as the most common cause of alopecia in patients with systemic lupus erythematosus, with trichoscopy proving effective in diagnosing different alopecia patterns.

research Validation of the Cutaneous Lupus Disease Area and Severity Index (CLASI) using physician- and patient-assessed health outcome measures

40 citations , October 2012 in “Journal of the American Academy of Dermatology”

This study found that the Cutaneous Lupus Disease Area and Severity Index (CLASI) is correlated with both physician-assessed and patient-reported outcomes in cutaneous lupus erythematosus, particularly highlighting concerns about body image in visible areas.

research PD-1+CXCR5−CD4+T cells are correlated with the severity of systemic lupus erythematosus

71 citations , May 2019 in “Rheumatology”

This study observed that PD-1+CXCR5-CD4+T peripheral helper cells are significantly elevated in patients with systemic lupus erythematosus and are correlated with disease activity indicators, suggesting their potential role in lupus pathogenesis.

research Trichoscopic signs in systemic lupus erythematosus: a comparative study with 109 patients and 305 healthy controls

29 citations , January 2019 in “Journal of the European Academy of Dermatology and Venereology”

This study found that trichoscopic examination is useful for diagnosing and monitoring systemic lupus erythematosus, with severe diffuse non-scarring alopecia indicating active disease.

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learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn Salicylic acid

What makes alopecia areata different from other types of hair loss, and can topical Salicylic acid treatments help regrow the affected areas? Alopecia areata is an autoimmune condition, and salicylic acid does not promote hair regrowth.

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Community Join

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community Random bald spot suddenly appeared

212 upvotes 3 weeks ago

A user noticed a sudden bald spot and others suggested it might be alopecia areata, often stress-induced, recommending seeing a dermatologist for steroid injections. Topical minoxidil was mentioned as a successful treatment by one user.

community Pilose antler extracts promotes hair growth in androgenetic alopecia mice by activating hair follicle stem cells via the AKT and Wnt pathways

11 upvotes 2 years ago

Pilose antler extracts may promote hair growth in androgenetic alopecia by activating hair follicle stem cells through the AKT and Wnt pathways. However, results in mice may not directly apply to humans due to differences in genetic and biochemical conditions.

community Bruteforcing alopecia or the new advent of science progress

22 upvotes 1 year ago

Combining therapies like scyllo-inositol, alpha-ketoglutarate, and autophagy-inducing supplements may enhance hair growth and prevent hair loss. Reporting individual results can accelerate progress in hair loss treatments.

community Fibrosing alopecia in a pattern distribution

in Research/Science 14 upvotes 2 years ago

A user has been experiencing hair loss for 4 years, with treatments like minoxidil, finasteride, and various supplements proving ineffective. They were diagnosed with fibrosing alopecia in a pattern distribution, a condition that may require a combination of anti-inflammatory and hair growth treatments.

community Alopecia Areata Question

2 upvotes 5 years ago

A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

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