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Alpha-Mangostin, a Safe and Natural Product as a Candidate Skin-Whitening Agent

research α-Mangostin, a safe and natural product as a candidate skin-whitening agent

December 2025 in “Scientific Reports”

In this laboratory study, α-mangostin was found to significantly reduce melanin content and downregulate pigmentation-related genes in cultured skin and B16F10 cells, suggesting potential application as a natural whitening agent in sunscreen development.

A Selection of Eleven Plants Used as Traditional Polynesian Cosmetics and Their Development Potential as Anti-Aging Ingredients, Hair Growth Promoters, and Whitening Products

research A selection of eleven plants used as traditional Polynesian cosmetics and their development potential as anti-aging ingredients, hair growth promoters and whitening products

13 citations , August 2019 in “Journal of Ethnopharmacology”

This study assessed 11 plants from French Polynesia for their potential development as sustainable natural cosmetics, particularly anti-aging and hair care products, based on their traditional uses and preliminary screening results.

research The transdermal inhibition of melanogenesis by a cell-membrane-permeable peptide delivery system based on poly-arginine

36 citations , March 2014 in “Biomaterials”

This study found that the 11R-No. 10 peptide, delivered transdermally, significantly inhibited melanogenesis and produced a whitening effect in a UV-induced sun-tanning guinea pig model without cytotoxicity.

research Antimelanogenic effect of ginsenoside Rg3 through extracellular signal-regulated kinase-mediated inhibition of microphthalmia-associated transcription factor

33 citations , January 2015 in “Journal of Ginseng Research”

This study found that ginsenoside Rg3 significantly inhibited melanogenesis in human melanocytes and B16F10 cells by activating the ERK pathway, suggesting potential as a skin-whitening agent.

[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) Inhibits SCF/c-kit Signaling in 501mel Human Melanoma Cells and Abolishes Melanin Production in Mice and Brownish Guinea Pigs

research [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs

26 citations , July 2007 in “Biochemical Pharmacology”

This study found that phenyl-imidazole sulfonamide derivatives, particularly ISCK03, inhibited c-kit signaling and promoted depigmentation in various experimental settings, suggesting potential use as skin-whitening agents.

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community Adam Scott and Rob Lowe talk about both taking finasteride for years starting at :38 seconds in

in Finasteride/Dutasteride 632 upvotes 1 year ago

Adam Scott and Rob Lowe have used finasteride for over 20 years to maintain their hair without significant negative effects. Many Hollywood celebrities use finasteride, minoxidil, and other treatments for hair loss, despite some concerns about side effects.

community PSA: Most men who stay on Fin will see the sexual side effects go away. Stop the fear mongering

192 upvotes 4 years ago

Finasteride can cause sexual side effects in less than 2% of men, but these often disappear over time, even if the treatment continues. Some users report persistent side effects, while others experience no issues or only temporary ones.

community I understand this topic has been discussed countless times, but hair loss is the most brutal experience for men.

in Chat 343 upvotes 1 year ago

Hair loss significantly affects men's confidence and mental health. Common treatments include finasteride, dutasteride, and minoxidil, with some considering hair transplants.

community "Finasteride Lore: Reversing Hair Loss Takes Years. Not Months." for all the people who worry about results after 3 months on Finasteride, or even worse stop taking it becuase "it wasn't working for me

in Finasteride/Dutasteride 140 upvotes 2 years ago

Finasteride can take years to show results, not months. Dutasteride may work faster but is less commonly prescribed.

community Rosemary oil + peppermint oil as an alternative to Minoxidil!!

4 upvotes 4 years ago

Rosemary and peppermint oils are suggested as natural alternatives to minoxidil for hair growth, with added benefits for skin health. Some users report positive results, though there is debate about their effectiveness compared to minoxidil.

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