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Research

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research Skin shedding and tissue regeneration in African spiny mice (Acomys)

418 citations , September 2012 in “Nature”

This study reports the first instance of skin autotomy in mammals, specifically in African spiny mice, and suggests they may possess a greater regenerative capacity than previously understood, possibly offering insights for regenerative medicine.

A Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Effects of a Polyphenol-Rich Fruit Extract Combined with Biotin on Wrinkle Morphology, Skin Surface Roughness, and Hair Shedding

research A Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Effects of a Polyphenol-Rich Fruit Extract Combined with Biotin on Wrinkle Morphology, Skin Surface Roughness, and Hair Shedding

June 2026 in “Cosmetics”

In this study, a polyphenol and biotin supplement improved skin roughness and significantly reduced hair shedding, but did not demonstrate clear superiority over placebo in overall skin outcomes.

research Skin and hair regeneration after calciphylaxis. Histologic changes during formation and shedding of the calciphylactic carapace of the rat

August 1969 in “Archives of Dermatology”

In this study, histologic analysis of rat skin with localized calciphylaxis indicated that although the skin showed potential for regeneration, the result was incomplete and resembled scar tissue with diminished hair presence.

research Shedding Light on the Effects of Calorie Restriction and Its Mimetics on Skin Biology

6 citations , May 2020 in “Nutrients”

This review discusses the effects of calorie restriction on skin aging, highlighting its potential to benefit skin health by reducing age-related and photo-induced changes, although the impact of certain diets remains unexplored.

research 371 Hair follicles are critical modulators of skin barrier function

July 2024 in “Journal of Investigative Dermatology”

Hair follicles are crucial for maintaining skin barrier function.

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Community Join

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community Do you see skin shedding with micro needling?

in Microneedling 6 upvotes 1 year ago

Microneedling can cause skin shedding and inflammation, with some users adjusting needle size or frequency to reduce these effects. Some users combine microneedling with treatments like minoxidil, while others prefer smaller needles or alternative treatments like dutasteride.

community 8 months on dut and just keep shedding

in Finasteride/Dutasteride 4 upvotes 9 months ago

The user experienced increased shedding and side effects like oily skin and acne after switching from finasteride to dutasteride, despite initially having success with finasteride. They also tried oral spironolactone, which reduced libido but didn't help with hair loss, and are considering returning to finasteride only.

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Learn

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learn Stemoxydine

chemical from L'Oreal that encourages hair to enter growth phase

learn Vascular Endothelial Growth Factor

learn Overview

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Thymosin Beta 4

learn Melatonin

Can melatonin cause side effects on the skin or hair? Melatonin may cause hair loss or thinning in some users, but evidence is limited.

learn Scalp Micropigmentation

Does scalp micropigmentation work on all skin tones and hair colors? Scalp micropigmentation can be customized for various skin tones and hair colors.
Is scalp micropigmentation suitable for people with sensitive skin? Providers say scalp micropigmentation suits most skin types and describe patch tests, hypoallergenic pigments and a skin consultation for sensitive skin. These are provider claims rather than independent safety evidence, and pigment reactions remain a risk.