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research Evolution of hard proteins in the sauropsid integument in relation to the cornification of skin derivatives in amniotes

86 citations , April 2009 in “Journal of anatomy”

This paper reviews the evolution of skin appendages and keratin-associated proteins among amniotes, proposing a model for their genetic divergence without new experimental results.

research Coumarin derivatives, but not coumarin itself, cause skin irritation via topical delivery

15 citations , February 2014 in “Toxicology Letters”

This study found that osthole, a coumarin derivative, demonstrated significantly higher skin accumulation and potential skin irritation compared to coumarin, which showed negligible alterations in protein biomarkers.

research Novel Quinazoline Derivative Induces Differentiation of Keratinocytes and Enhances Skin Barrier Functions against Th2 Cytokine-Mediated Signaling

2 citations , August 2023 in “Molecules”

This study found that a quinazoline derivative, SH-340, increased skin barrier-associated factors and inhibited TSLP expression and STAT6 phosphorylation in human primary keratinocytes, suggesting potential benefits for alleviating inflammation and improving skin barrier function in atopic dermatitis.

research Light‐Activatable Hyaluronic Acid‐Derivatives Releasing Nitric Oxide and Their Delivery in the Skin

3 citations , April 2025 in “Advanced Healthcare Materials”

In this study, researchers developed hyaluronic acid derivatives functionalized with nitric oxide photodonors for light-activated skin treatments, finding that the compounds released NO under blue light and enhanced keratinocyte proliferation and migration, suggesting potential for therapeutic use.

research STRUCTURAL-FUNCTIONAL REORGANIZATION OF SKIN AND ITS DERIVATIVES UNDER EXPERIMENTAL SUBACUTE OF INTOXICATION BY HEAVY METALS

1 citations , March 2019 in “Hygiene and Sanitation”

This study observed that exposure to heavy metal salts affected skin and hair morphology in mice, with lead acetate decreasing keratinocyte proliferation and zinc sulfate and sodium dichromate increasing it.

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Community Join

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community Minoxidil without coconut derivatives? (coconut allergy) (glycerin, cetyl alcohol)

1 upvotes 2 years ago

A user is seeking a Minoxidil solution without coconut derivatives due to a coconut allergy and is considering DIY options from pure Minoxidil tablets. They mention that Rogaine contains glycerin and cetyl alcohol, which are derived from coconut.

community Finasteride and “anti-aging” effects

in Treatment 218 upvotes 1 year ago

Finasteride may help users look younger by suppressing DHT, affecting skin and hair. Users also emphasize skincare, sunscreen, and lifestyle for maintaining a youthful appearance.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

76 upvotes 2 years ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Whey Protein can cause hairloss in men with AGA as per a doctor

64 upvotes 8 months ago

Whey protein may slightly increase hair loss in men with androgenetic alopecia (AGA) due to elevated IGF-1 and testosterone levels, but the effect is minimal compared to treatments like finasteride and dutasteride. Many users argue that whey protein's impact on hair loss is negligible and that maintaining a healthy lifestyle is more important.

community Why Fin/Dut is always recommended. The top 10 reasons for hairloss in men.

2 upvotes 1 year ago

Hair loss in men is primarily caused by androgenetic alopecia, with treatments like finasteride and dutasteride often recommended. Other causes include stress, nutritional deficiencies, medications, and scalp infections.

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Learn

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learn Tretinoin

the gold standard retinoid in dermatology that's also helpful for hair regrowth alongside Minoxidil

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn Overview

learn Melatonin

Can melatonin cause side effects on the skin or hair? Melatonin may cause hair loss or thinning in some users, but evidence is limited.

learn Scalp Micropigmentation

Does scalp micropigmentation work on all skin tones and hair colors? Scalp micropigmentation can be customized for various skin tones and hair colors.
Is scalp micropigmentation suitable for people with sensitive skin? Providers say scalp micropigmentation suits most skin types and describe patch tests, hypoallergenic pigments and a skin consultation for sensitive skin. These are provider claims rather than independent safety evidence, and pigment reactions remain a risk.

learn retinol

How does retinol improve scalp health and prepare the skin for other hair growth treatments? Retinol improves scalp health by promoting cellular turnover and reducing congestion.

learn Hyaluronic Acid

Does hyaluronic acid really hydrate the scalp, or is it mainly for skin care? Hyaluronic acid can hydrate the scalp, but its effectiveness may vary.

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Clinics

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Experts

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35
SMP Specialist
Noelle Skin
Nice, France

Noelle Skin