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research Combining Laser Capture Microdissection and RNAseq Analysis to Generate a Human Anagen Hair Follicle Transcriptome Atlas

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Researchers made a detailed map of gene activity for different parts of human hair follicles to help create targeted hair disorder treatments.

research Shh Maintains Dermal Papilla Identity and Hair Morphogenesis via a Noggin–Shh Regulatory Loop

138 citations , June 2012 in “Genes & Development”

Sonic hedgehog signaling is crucial for hair growth and maintaining hair follicle identity.

research Stabilization of Epithelial Beta-Catenin Compromises Mammary Cell Fate Acquisition and Branching Morphogenesis

August 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Too much β-catenin activity can mess up the development of mammary glands and make them more like hair follicles.

research Transcriptomic Analysis to Identify Protective Dermal Papilla Signature in Occipital Scalp

April 2021 in “Journal of Investigative Dermatology”

The research found genes that may protect certain scalp cells from hair loss.

Effect of Scenedesmus Deserticola JD052 Extracts on Hair Inductivity by Regulating the AKT and GSK3β/β-Catenin Signaling Pathways in Human Dermal Papilla Cells

research Effect of Scenedesmus Deserticola JD052 Extracts on Hair Inductivity by Regulating the AKT and GSK3β/β-Catenin Signaling Pathways in Human Dermal Papilla Cells

February 2025 in “Applied Sciences”

Scenedesmus deserticola JD052 extracts may help hair growth and could be a natural treatment for hair loss.

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Community Join

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community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System

in Research/Science 64 upvotes 5 months ago

PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.

community 3 months of minoxidil foam. No fin or derma rolling

in Minoxidil 700 upvotes 3 years ago

This user has had success with Minoxidil foam, achieving significant hair growth in three months without using finasteride or derma rolling. They are considering incorporating a DHT reducing strategy such as finasteride in the future.

community is this a hair transplant (57 yo)

in Hair Systems 602 upvotes 2 weeks ago

A 57-year-old man uses a hair system, not a hair transplant, and likely had cosmetic procedures. Discussions include the effectiveness of hair systems and finasteride side effects.

community DHT and 5AR respect post, it's importance within the brain

in Research/Science 111 upvotes 2 years ago

The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

community 3 years on fin and 1 year on min. Diffuse thinner Asian hair. More hair than high school.

in Progress Pictures 761 upvotes 3 years ago

A user's experience with using finasteride and minoxidil to treat hair loss; they experienced minimal regrowth with finasteride alone, but significant regrowth with the combination of finasteride and minoxidil.

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