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      learn SCUBE3

      a signaling molecule from dermal papilla cells being actively researched

      learn PP405

      mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials

      learn Exosomes

      Microscopic delivery system that sends growth-promoting signals to hair follicles

      learn HMI-115

      much-hyped research compound targeting prolactin receptor in scalp

      learn Follistatin

      glycoprotein that inhibits TGF-β and promotes hair growth by antagonizing activin

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      community Does drinking coffee offset the effects of Minoxidil?

      in Minoxidil  16 upvotes 5 months ago
      The conversation discusses whether drinking coffee affects the hair growth benefits of Minoxidil, with one user mentioning that Minoxidil's vasodilation is stronger than caffeine's vasoconstriction, and another sharing personal experience of better hair growth after quitting caffeine while on Minoxidil.

      community Trestolone (MENT) as a nuclear treatment

      in Treatment  99 upvotes 2 years ago
      Experimenting with trestolone as a treatment for hair loss in an attempt to avoid DHT-related treatments such as finasteride and dutasteride, and discussing the potential effects of its receptor selectivity on the androgen receptors in the scalp.

      community Testosterone and hair loss seeming irrelevance

      in Research/Science  82 upvotes 1 year ago
      The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

      community Comprehensive Microneedling Guide

      in Microneedling  287 upvotes 2 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community HLT Megathread on HMI-115 (key takeaways in comments)

      in Research/Science  40 upvotes 1 year ago
      HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.