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GlossaryHair Miniaturization (Shrunken Hair Follicles)

hair follicles shrink, producing thinner and shorter hair strands

Hair miniaturization is a process where hair follicles shrink over time, producing thinner, shorter, and less pigmented hair strands. This phenomenon is commonly associated with androgenetic alopecia (pattern baldness) and can eventually lead to the follicles becoming dormant and ceasing to produce hair altogether.

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research Differential Diagnosis of Female-Pattern Hair Loss

3 citations , January 2016 in “Skin appendage disorders”

Possible causes of female hair loss include androgenetic alopecia, telogen effluvium, cicatricial alopecia, and alopecia areata incognita; diagnosis and treatment require dermoscopy and histopathology.

research Epidermal Dysplasia and Abnormal Hair Follicles in Transgenic Mice Overexpressing Homeobox Gene MSX-2

49 citations , August 1999 in “Journal of Investigative Dermatology”

Overexpressing the MSX-2 gene in mice causes skin and hair growth issues.

research A Role for p75 Neurotrophin Receptor in the Control of Apoptosis-Driven Hair Follicle Regression

96 citations , October 2000 in “The FASEB Journal”

The p75 neurotrophin receptor is important for hair follicle regression by controlling cell death.

research Potential Remedial Effects of Solanum Nigrum Berries on Alopecia: An In Vivo Study

January 2024 in “Journal of Natural Remedies”

Solanum nigrum extract may help regrow hair.

research Clinical Results of Platelet-Rich Plasma Injection in the Treatment of Androgenetic Alopecia

March 2019 in “European archives of medical research”

Platelet-rich plasma injections are a cheap and effective way to reduce hair loss and improve hair quality in people with mild to moderate androgenetic alopecia.

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community Taking Charge of Your Hair: The "Big 3 Stack" Explained for 2023

in Research/Science 129 upvotes 2 years ago

The "Big 3 Stack" for hair loss treatment, which includes Minoxidil for hair density improvement, Ketoconazole shampoo for enhancing hair volume and thickness, and Finasteride for blocking hair loss causing hormones. Microneedling can boost Minoxidil's effects.

community Reminder: NURTURE those dormant hair follicles for as long as you can until PP405 comes out in 2028-2030

in Treatment 191 upvotes 3 months ago

PP405 is anticipated as a future treatment for dormant hair follicles, but its effectiveness and safety are uncertain. Current treatments include oral minoxidil and microneedling, with some avoiding finasteride due to side effects.

community If Minoxidil Beards are permanent, why should Finasteride be unable to keep Minoxidil Gains on the scalp?

in Minoxidil 104 upvotes 3 years ago

Whether Finasteride can keep alive the hair gained by Minoxidil after quitting it, and why beard hairs are not as susceptible to miniaturization. It is suggested that scalp hair may be dependent on Minoxidil and that DHT could be countered with Finasteride to some extent, but there is no definitive data proving this.

community 4.5 month finasteride update! What a difference hair makes! To all the people that say just shave it bro, just no.

in Progress Pictures 1593 upvotes 5 years ago

A user's progress pictures and four month finasteride update showing dramatic hair regrowth, as well as their experiences with other treatments like minoxidil. The conversation also includes advice on diet, testosterone levels, and the importance of avoiding baldness for attraction and confidence.

community Finasteride gains continue well into year 5

in Chat 118 upvotes 1 year ago

Finasteride can continue to improve hair loss for up to 10 years, with the best results seen when started early. Combining treatments like minoxidil, dermarolling, or RU58841 may enhance effectiveness.

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