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research Exogen, Shedding Phase of the Hair Growth Cycle: Characterization of a Mouse Model

107 citations , September 2002 in “Journal of Investigative Dermatology”

This study identified a distinct "exogen" phase in the hair cycle during which hair shedding occurs, primarily coupled with the anagen phase, rather than as part of the telogen phase.

research Whether the transient hair shedding phase exist after minoxidil treatment and does it predict treatment efficacy? A retrospective study in androgenetic alopecia patients

March 2025 in “Journal of Dermatological Treatment”

This study explored whether using topical minoxidil can temporarily increase hair shedding, but results are not reported.

research Shedding light on cashmere goat hair follicle biology: from morphology analyses to transcriptomic landascape

8 citations , July 2020 in “BMC genomics”

In this study, ceruloplasmin and keratin 4 were identified as markers that differentiate between growing and resting phases in cashmere goat hair follicles, with keratin 4 being a potential marker for the onset of a new hair cycle.

research The role of mimicking growth factors to control anagen phase: Evaluation in vitro and in vivo

February 2010 in “Journal of The American Academy of Dermatology”

Mimicking growth factors in a topical solution can prolong hair growth phase and reduce hair loss without side effects.

research Chronic telogen effluvium: Increased scalp hair shedding in middle-aged women

234 citations , December 1996 in “Journal of The American Academy of Dermatology”

The authors concluded that chronic telogen effluvium in middle-aged women presents distinct clinical and histological features that differ from androgenetic alopecia and acute telogen effluvium.

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Community Join

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community Shedding phase... It's brutal lol

in Progress Pictures 8 upvotes 4 months ago

The user is using finasteride and topical minoxidil for hair loss after previously trying them separately without success. They are experiencing a shedding phase but are committed to the treatment.

community Third shedding phase on less than 6 months of treatment

in Chat 7 upvotes 4 months ago

The user has been using minoxidil for almost 6 months and finasteride for almost 4 months, experiencing significant shedding and minimal stabilization. They are considering switching to dutasteride if no improvements are seen and are advised to be patient, as results may take up to 2 years.

community This shedding phase is brutal man…

590 upvotes 1 year ago

The user is experiencing a difficult shedding phase after starting a hair loss treatment with oral finasteride, topical minoxidil, and microneedling. Despite the shedding, they remain hopeful for regrowth and plan to continue the treatment, encouraged by others' positive results.

community Dutasteride shedding phase while in Minoxidil

in Treatment 4 upvotes 2 years ago

The user experienced hair shedding with finasteride and found minoxidil helpful for regrowth but insufficient alone. They are considering dutasteride but are concerned about potential shedding similar to their experience with finasteride.

community 2.5 years on fin + min – regrowth, shedding phases, LLLT stabilized

in Progress Pictures 45 upvotes 5 months ago

The user experienced regrowth and stabilization in hair density using finasteride, minoxidil, a derma roller, and an LLLT helmet, but noticed a recent decline in hair quality. They only take finasteride orally and are unsure about the effectiveness of the LLLT device.

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Learn

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learn Finasteride

Finasteride Results Timeline: How Long It Takes to Work, Shedding Phases, and Expected Outcomes Trial data and community reports both put the first visible changes on finasteride at roughly 3 to 6 months, with the clearest results between 6 and 12 months; some people report an early increase in shedding, but how often this happens has not been measured. The benefit lasts only while the drug is taken, it is prescription-only, and its labels warn of sexual side effects that have continued after stopping in some men, of depression and suicidal thoughts, and of breast and semen changes; some former users also report anxiety and cognitive complaints (see "Is finasteride safe?").

learn Hair Transplant

Is shedding normal after a hair transplant? Shedding of transplanted hairs 1–8 weeks after surgery is expected, and regrowth usually starts at 3–5 months. Shock loss of nearby native hair can also happen, so ask your surgeon if shedding persists.

learn PP405

Can PP405 help bald patches caused by stress? PP405 is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier; its registered Phase 2 trial (NCT06393452) tested it once daily in 78 adults with pattern hair loss, for safety and tolerability. It is not approved, not for sale, and has not been studied in alopecia areata or stress-related shedding.

learn Fluridil

Topical anti-androgen sold as a cosmetic lotion

learn Stemoxydine

Cosmetic ingredient made by L'Oréal

learn Minoxidil

Vasodilator used on the scalp and, at low doses, as a tablet

learn Botox

Can Botox reduce chronic hair shedding? Whether Botox reduces chronic shedding is unknown: one very small 2022 trial in telogen effluvium had no placebo arm, and the blood-flow theory is unproven. Scalp Botox for hair loss is off-label, and all botulinum toxin products carry an FDA boxed warning.

learn Piroctone Olamine

Can Piroctone Olamine reduce hair shedding caused by scalp irritation? Small studies suggest piroctone olamine shampoo may reduce shedding in people with dandruff. It does not treat pattern hair loss.

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