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research Effects of depot medroxyprogesterone acetate, the copper IUD and the levonorgestrel implant on testosterone, sex hormone binding globulin and free testosterone levels: ancillary study of the ECHO randomized clinical trial
This study found that free testosterone levels were 29% higher with the levonorgestrel implant than with the DMPA injection, which may impact sexual function, mood, and side effects like acne.
research The injectable contraceptives depot medroxyprogesterone acetate and norethisterone enanthate substantially and differentially decrease testosterone and sex hormone binding globulin levels: A secondary study from the WHICH randomized clinical trial
In this study, researchers reported that both progestin-only injectable contraceptives, DMPA-IM and NET-EN, significantly decreased serum testosterone and SHBG levels among HIV-negative women in South Africa, yet this did not explain prior findings of no reduction in risky sexual behavior or sexual function.
research Inhibitors of 5α-reductase-related side effects in patients seeking medical care for sexual dysfunction.
This study found that in men with sexual dysfunction, use of 5ARI may reduce sexual drive and spontaneous erections without worsening pre-existing erectile or ejaculatory issues.
research 104 Flibanserin Subset Analyses and the Androgenics of Hypoactive Sexual Desire Disorder
This study found no baseline factors that predicted flibanserin efficacy for HSDD, though low testosterone or use of hormonal contraceptives were associated with reduced efficacy.
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5 / 1000+ resultscommunity Is ED after taking Fin or Dut caused by less DHT or an increase in Estrogen/Estradiol
Finasteride and dutasteride may cause erectile dysfunction due to reduced DHT, affecting nitric oxide and sexual function. Some suggest using aromatase inhibitors to address side effects, while others believe individual sensitivity to DHT reduction varies.
community My Experience With Finasteride
A user shared their experience with Finasteride for hair loss, noting a significant reduction in DHT levels and a complete loss of libido without other side effects. Another user agreed, discussing the negative impact on sexual drive and criticizing the community's attitude towards discussing side effects.
community 52 y.o. here. After being on 1 mg finasteride on and off since almost 30 years ago (consistently on for the past 9 years), I'm switching to dutasteride as of today.
A 52-year-old is switching from finasteride to dutasteride to address crown balding, despite concerns about potential side effects. They have used finasteride for nearly 30 years, had a minor hair transplant, and are considering further treatments if dutasteride doesn't improve their condition.
community Does finasteride decrease free testosterone?
Finasteride may decrease free testosterone by increasing SHBG, potentially causing side effects like reduced libido and hormonal changes. Some find it effective for hair loss, while others experience negative effects.
community 17years on fin, now 38 and I haven’t had too much loss since then
A 38-year-old has maintained hair with finasteride for 17 years, recently adding oral minoxidil for improvement. Users discuss experiences with finasteride, dutasteride, and minoxidil, noting effectiveness, side effects, and costs.
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learn Osteopontin
signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
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