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research Cyclosporine for moderate-to-severe alopecia areata: A double-blind, randomized, placebo-controlled clinical trial of efficacy and safety

44 citations , April 2019 in “Journal of the American Academy of Dermatology”

This study observed that cyclosporine showed a trend toward improving alopecia areata symptoms compared to placebo, but the difference was not statistically significant.

research Alefacept for Severe Alopecia Areata

43 citations , November 2009 in “Archives of dermatology”

This study found that alefacept showed no significant improvement in treating severe alopecia areata compared to placebo over a 24-week period.

research Treatment of moderate-to-severe alopecia areata in pre-adolescent children with baricitinib

17 citations , April 2023 in “British Journal of Dermatology”

This study suggests that off-label use of baricitinib in children under 12 with alopecia areata may improve hair regrowth, but further research is needed to confirm efficacy and safety.

research Ritlecitinib for Severe Alopecia Areata: A 24-Week, Multicentre, Real-World Study

1 citations , March 2026 in “American Journal of Clinical Dermatology”

In this Italian retrospective study, ritlecitinib 50 mg/day showed effectiveness and good tolerability for treating severe alopecia areata over 24 weeks, achieving significant hair regrowth particularly in adolescents, as well as improvements in eyebrows, eyelashes, nails, and quality of life, with mostly mild adverse effects.

research Upadacitinib for Severe Alopecia Areata in Adults and Adolescents

August 2026 in “JAMA Dermatology”

This study found that upadacitinib significantly improved hair regrowth compared to placebo in adults and adolescents with severe alopecia areata, and demonstrated a positive benefit-risk profile.

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Community Join

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community Sexual Dysfunction in Those with Androgenetic Alopecia on Dutasteride Versus Finasteride

in Finasteride/Dutasteride 113 upvotes 1 year ago

Dutasteride and finasteride have similar risks of sexual dysfunction for treating androgenetic alopecia. Users experience varying side effects, indicating individual differences in drug reactions.

community DHT Harms Scalp Microbiome: DHT Itch is REAL

413 upvotes 1 year ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community Finasteride does deplete important nuero-active steroids

11 upvotes 3 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

community Article of all potential future cures

25 upvotes 1 year ago

Ritlecitinib and PP405 show promise for hair regrowth. Diagnosing the cause of hair loss is crucial before treatment.

community Clascoterone 12 months phase 3 result out

42 upvotes 5 months ago

Clascoterone is promising for hair loss, showing 24.5% improvement in satisfaction compared to placebo. Users consider it an alternative to finasteride, with concerns about absorption and side effects.

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Learn

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learn Microneedling

technique to create small wounds in skin to activate collagen production and hair growth

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Scalp Micropigmentation

Is scalp micropigmentation suitable for all types of hair loss? Scalp micropigmentation is generally suitable for various types of hair loss.
Can scalp micropigmentation hide my scars? Scalp micropigmentation can significantly reduce the visibility of scars on the scalp.
What is Scalp Micropigmentation and how does it help people with visible hair loss? Scalp Micropigmentation creates the illusion of hair follicles on the scalp for visible hair loss.

learn Tofacitinib

a JAK inhibitor for alopecia areata and other autoimmune conditions

What is tofacitinib, and why is it discussed in relation to autoimmune-related hair loss such as alopecia areata? Tofacitinib is a prescription JAK inhibitor approved for rheumatoid arthritis, psoriatic arthritis and ulcerative colitis — not for alopecia areata. It is discussed for hair loss because a 2014 case report and a 2016 open-label trial reported regrowth in severe alopecia areata, but that use is off-label, the regrowth relapsed after stopping, and the drug carries an FDA boxed warning.
What types of hair loss conditions are most commonly associated with tofacitinib use in clinical settings? Published studies link tofacitinib mainly to alopecia areata and its severe variants — as an off-label drug being studied for them, not as a cause of hair loss. The evidence is mostly small, open-label or retrospective, and relapse after stopping is commonly reported.

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