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This study discusses how redox imbalance, specifically through reduced Insulin-like Growth Factor-1 mediated by the transcription factor JunB and sphingolipid metabolism changes, contributes to skin aging by depleting stem cell pools and altering the extracellular matrix, ultimately impacting skin integrity and function.

In this study, aged mice showed better regenerative skin outcomes than young mice, linked to a specific fibroblast subpopulation and enhanced signaling interactions that promote regeneration. EREG treatment improved young mice's skin regeneration, suggesting potential for scarless therapies.

This study identified Azithromycin and Roxithromycin as novel senolytic antibiotics that effectively target and reduce senescent human fibroblast cells.

Reactive lipids from aging cells change the extracellular matrix, affecting cell function and inflammation.

This study found that the small molecule honokiol may protect against inflammation, collagen breakdown, and cell damage caused by cigarette smoke in skin cells cultured in vitro.